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Verfasst von:Schäfer, Michael [VerfasserIn]   i
 Gross, Wolfgang [VerfasserIn]   i
 Gebhard, Martha-Maria [VerfasserIn]   i
Titel:Hearts during ischemia with or without HTK-protection analysed by dielectric spectroscopy
Verf.angabe:Michael Schaefer, Wolfgang Gross and Martha-Maria Gebhard
E-Jahr:2018
Jahr:26 February 2018
Teil:volume:39
 year:2018
 number:2
Fussnoten:Gesehen am 24.05.2019
Titel Quelle:Enthalten in: Physiological measurement
Ort Quelle:Bristol : IOP Publ., 1980
Jahr Quelle:2018
Band/Heft Quelle:39(2018,2) Artikel-Nummer 025002, ? Seiten
ISSN Quelle:1361-6579
Abstract:Objective: We investigated canine hearts during ischemia after aortic cross clamping (UI, n = 20) and after HTK-cardioplegia (HTK, n = 24) at 35 °C, 25 °C, 15 °C, and 5 °C with the aim to compare tissue changes caused by the activity of anaerobic metabolism(AAM), cell membrane destruction(CD), and gap junction uncoupling(GJU). Approach: We measured continuously the complex dielectric spectrum(DS), ATP- and lactate content, extracellular pH, and rigor contracture. To identify changes in DS caused by AAM, CD, and GJU we performed additional experiments on the gap junction-free skeletal muscle. We used heart model simulations to calculate the effect of temperature. Main results: AAM affected the DS at 10 MHz and we found a strong correlation between DS and the proton concentration with a maximum of DS at 10 mmol g−1 dry weight in ATP-concentration. The time of GJU was detected by a characteristic increase in DS and CD by a characteristic decrease at 13 kHz. In comparison to UI, GJU, AAM and CD were delayed by HTK and by hypothermia, indicating a minimization of energy consumption and an improved preservation of tissue structure. Significance: The novel findings were that in UI at 5 °C GJU occurred earlier and AAM remained constant, indicating a less effective preservation in UI by deep hypothermia in contrast to HTK.
DOI:doi:10.1088/1361-6579/aaa575
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1088/1361-6579/aaa575
 Volltext: https://doi.org/10.1088%2F1361-6579%2Faaa575
 DOI: https://doi.org/10.1088/1361-6579/aaa575
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1666283436
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