Status: Bibliographieeintrag
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| Verfasst von: | Gutting, Tobias [VerfasserIn]  |
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| | Burgermeister, Elke [VerfasserIn] |
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| | Härtel, Nicolai [VerfasserIn] |
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| | Ebert, Matthias [VerfasserIn] |
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| Titel: | Checkpoints and beyond - immunotherapy in colorectal cancer |
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| Verf.angabe: | Tobias Gutting, Elke Burgermeister, Nicolai Härtel, Matthias P. Ebert |
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| Jahr: | 2019 |
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| Jahr des Originals: | 2018 |
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| Umfang: | 12 S. |
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| Fussnoten: | Available online 30 April 2018 ; Gesehen am 27.05.2019 |
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| Titel Quelle: | Enthalten in: Seminars in cancer biology |
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| Ort Quelle: | London : Academic Press, 1995 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 55(2019), Seite 78-89 |
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| ISSN Quelle: | 1096-3650 |
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| Abstract: | Immunotherapy is the latest revolution in cancer therapy. It continues to show impressive results in malignancies like melanoma and others. At least so far, effects are modest in colorectal cancer (CRC) and only a subset of patients benefits from already approved checkpoint inhibitors. In this review, we discuss major hurdles of immunotherapy like the immunosuppressive niche and low immunogenicity of CRC next to current achievements of checkpoint inhibitors, interleukin treatment and adoptive cell transfer (dendritic cells/cytokine induced killer cells, tumor infiltrating lymphocytes, chimeric antigen receptor cells, T cell receptor transfer) in pre-clinical models and clinical trials. We intensively examine approaches to overcome low immunogenicity by combination of different therapies and address future strategies of therapy as well as the need of predictive factors in this emerging field of precision medicine. |
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| DOI: | doi:10.1016/j.semcancer.2018.04.003 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.semcancer.2018.04.003 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S1044579X17302687 |
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| | DOI: https://doi.org/10.1016/j.semcancer.2018.04.003 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Immunotherapy |
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| | Adoptive cell transfer |
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| | Checkpoint inhibitor |
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| | Colorectal cancer |
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| | Immunosuppressive niche |
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| K10plus-PPN: | 1666323063 |
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| Verknüpfungen: | → Zeitschrift |
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Checkpoints and beyond - immunotherapy in colorectal cancer / Gutting, Tobias [VerfasserIn]; 2019 (Online-Ressource)
68393075
