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Verfasst von:Coghlan, J. Gerry [VerfasserIn]   i
 Harutyunova, Satenik [VerfasserIn]   i
 Benjamin, Nicola [VerfasserIn]   i
 Fischer, Christine [VerfasserIn]   i
 Grünig, Ekkehard [VerfasserIn]   i
Titel:Incidence of pulmonary hypertension and determining factors in patients with systemic sclerosis
Verf.angabe:J. Gerry Coghlan, Matthias Wolf, Oliver Distler, Christopher P. Denton, Martin Doelberg, Satenik Harutyunova, Alberto M. Marra, Nicola Benjamin, Christine Fischer and Ekkehard Grünig
E-Jahr:2018
Jahr:[2018]
Umfang:11 S.
Illustrationen:Diagramme
Fussnoten:Gesehen am 28.05.2019
Titel Quelle:Enthalten in: European respiratory journal
Ort Quelle:Lausanne : ERS, 1988
Jahr Quelle:2018
Band/Heft Quelle:51 (2018,4) Artikel-Nummer 1701197, Seite 1-11, 11 Seiten
ISSN Quelle:1399-3003
Abstract:The objective of this study was to evaluate the incidence of pulmonary hypertension (PH) and determining factors in patients with systemic sclerosis (SSc) and a diffusing capacity of the lung for carbon monoxide (DLCO) <60% predicted. - In this bicentric, prospective cohort study, patients with SSc were clinically assessed at baseline and after 3 years, including right heart catheterisation (RHC). Analysis of determining factors for the development of PH was performed using univariate and multivariate analyses. - 96 patients with a mean pulmonary arterial pressure (mPAP) <25 mmHg at baseline were followed for 2.95±0.7 years (median 3 years). Of these, 71 had a second RHC; 18 of these 71 patients (25.3%) developed PH, and five (7%) developed SSc-associated pulmonary arterial hypertension. For patients with an mPAP of 21-24 mmHg at baseline, the likelihood of presenting with PH as opposed to normal pressures on follow-up was significantly higher (p=0.026). Pulmonary vascular resistance, tricuspid regurgitation velocity, diffusion capacity and the size of the inferior vena cava at baseline were independent predictors for the development of PH during follow-up. - In a selected cohort of SSc patients with a DLCO <60%, pulmonary pressures appeared to rise progressively during follow-up. In this population, it was possible to identify manifest PH in almost 25% of patients using prospective RHC during follow-up. Therefore, regular clinical assessment including RHC might be useful in patients with SSc. - Tweetable abstract @ERSpublications - click to tweetBorderline elevation of mPAP is associated with higher incidence of pulmonary hypertension in high-risk systemic sclerosis patients http://ow.ly/stXU30iyzrU
DOI:doi:10.1183/13993003.01197-2017
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1183/13993003.01197-2017
 Volltext: https://erj.ersjournals.com/content/51/4/1701197
 DOI: https://doi.org/10.1183/13993003.01197-2017
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1666389129
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