Contrast-enhanced fat-suppressed FLAIR for the characterization of leptomeningeal inflammation in optic neuritis

• Verfasst von: Pino-Lopez, Luis [VerfasserIn]
• Verfasst von: Wenz, Holger [VerfasserIn]
• Verfasst von: Böhme, Johannes [VerfasserIn]
• Verfasst von: Maros, Máté E. [VerfasserIn]
• Verfasst von: Schlichtenbrede, Frank [VerfasserIn]
• Verfasst von: Groden, Christoph [VerfasserIn]
• Verfasst von: Förster, Alex [VerfasserIn]
• Titel: Contrast-enhanced fat-suppressed FLAIR for the characterization of leptomeningeal inflammation in optic neuritis
• Verf.angabe: Luis Pino-Lopez, Holger Wenz, Johannes Böhme, Máté Maros, Frank Schlichtenbrede, Christoph Groden and Alex Förster
• Jahr: 2019
• Jahr des Originals: 2018
• Umfang: 9 S.
• Fussnoten: First Published: April 23, 2018 ; Gesehen am 28.05.2019
• Titel Quelle: Enthalten in: Multiple sclerosis journal
• Ort Quelle: London : Sage, 1995
• Jahr Quelle: 2019
• Band/Heft Quelle: 25(2019), 6, Seite 792-800
• ISSN Quelle: 1477-0970
• DOI: doi:10.1177/1352458518770268
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Contrast-enhanced
• Sach-SW: fat-suppressed
• Sach-SW: FLAIR
• Sach-SW: leptomeningeal inflammation
• Sach-SW: optic neuritis
• K10plus-PPN: 1666422576

Abstract

BACKGROUND: Leptomeningeal contrast enhancement on fluid-attenuated inversion recovery (FLAIR) images has been reported in patients with multiple sclerosis and interpreted as a biomarker of inflammation. In this study, we sought to evaluate this phenomenon in patients with optic neuritis (ON). - METHODS: A total of 42 patients with suspected ON were included in this prospective study and underwent a dedicated study magnetic resonance imaging (MRI) protocol including native and contrast-enhanced fat-suppressed thin-section axial and coronal FLAIR images on an 1.5 T magnetic resonance (MR) system. - RESULTS: After diagnostic workup, 34 patients with final diagnosis of ON were analyzed in detail. On contrast-enhanced fat-suppressed FLAIR images, 25 (73.5%) patients with ON demonstrated perioptic leptomeningeal enhancement, and in 3 (8.8%) patients, this was even the only pathological MRI finding. In comparison, patients with perioptic leptomeningeal enhancement on contrast-enhanced fat-suppressed FLAIR images had a higher prevalence of additional hyperintense brain lesions ( p = 0.022) as well as cerebrospinal fluid (CSF)-specific oligoclonal bands ( p = 0.013) than patients without. - CONCLUSION: Perioptic leptomeningeal contrast enhancement on fat-suppressed FLAIR images is a novel marker in ON and possibly reflects a leptomeningeal inflammatory process preceding or accompanying ON. Thin-section contrast-enhanced fat-suppressed FLAIR images might be a useful addition in MRI protocols for patients with suspected ON.