| |
 Online-Ressource | |
| Verfasst von: | Iotchkova, Valentina [VerfasserIn]  |
| Kleber, Marcus E. [VerfasserIn] | |
| März, Winfried [VerfasserIn] | |
| Titel: | Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps |
| Verf.angabe: | Valentina Iotchkova, Jie Huang, John A. Morris, Deepti Jain, Caterina Barbieri, Klaudia Walter, Josine L. Min, Lu Chen, William Astle, Massimilian Cocca, Patrick Deelen, Heather Elding, Aliki-Eleni Farmaki, Christopher S. Franklin, Mattias Franberg, Tom R. Gaunt, Albert Hofman, Tao Jiang, Marcus E. Kleber, Genevieve Lachance, Jian'an Luan, Giovanni Malerba, Angela Matchan, Daniel Mead, Yasin Memari, Ioanna Ntalla, Kalliope Panoutsopoulou, Raha Pazoki, John R. B. Perry, Fernando Rivadeneira, Maria Sabater-Lleal, Bengt Sennblad, So-Youn Shin, Lorraine Southam, Michela Traglia, Freerk van Dijk, Elisabeth M. van Leeuwen, Gianluigi Zaza, Weihua Zhang, Uk10k Consortium, Najaf Amin, Adam Butterworth, John C. Chambers, George Dedoussis, Abbas Dehghan, Oscar H. Franco, Lude Franke, Mattia Frontini, Giovanni Gambaro, Paolo Gasparini, Anders Hamsten, Aaron Issacs, Jaspal S. Kooner, Charles Kooperberg, Claudia Langenberg, Winfried Marz, Robert A. Scott, Morris A. Swertz, Daniela Toniolo, Andre G. Uitterlinden, Cornelia M. van Duijn, Hugh Watkins, Eleftheria Zeggini, Mathew T. Maurano, Nicholas J. Timpson, Alexander P. Reiner, Paul L. Auer and Nicole Soranzo |
| E-Jahr: | 2016 |
| Jahr: | 26 September 2016 |
| Umfang: | 10 S. |
| Fussnoten: | Gesehen am 28.05.2019 |
| Titel Quelle: | Enthalten in: Nature genetics |
| Ort Quelle: | London : Macmillan Publishers Limited, part of Springer Nature, 1992 |
| Jahr Quelle: | 2016 |
| Band/Heft Quelle: | 48(2016), 11, Seite 1303-1312 |
| ISSN Quelle: | 1546-1718 |
| Abstract: | Large-scale whole-genome sequence data sets offer novel opportunities to identify genetic variation underlying human traits. Here we apply genotype imputation based on whole-genome sequence data from the UK10K and 1000 Genomes Project into 35,981 study participants of European ancestry, followed by association analysis with 20 quantitative cardiometabolic and hematological traits. We describe 17 new associations, including 6 rare (minor allele frequency (MAF) < 1%) or low-frequency (1% < MAF < 5%) variants with platelet count (PLT), red blood cell indices (MCH and MCV) and HDL cholesterol. Applying fine-mapping analysis to 233 known and new loci associated with the 20 traits, we resolve the associations of 59 loci to credible sets of 20 or fewer variants and describe trait enrichments within regions of predicted regulatory function. These findings improve understanding of the allelic architecture of risk factors for cardiometabolic and hematological diseases and provide additional functional insights with the identification of potentially novel biological targets. |
| DOI: | doi:10.1038/ng.3668 |
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt. Volltext: https://doi.org/10.1038/ng.3668 |
| Volltext: https://www.nature.com/articles/ng.3668 | |
| DOI: https://doi.org/10.1038/ng.3668 | |
| Datenträger: | Online-Ressource |
| Sprache: | eng |
| K10plus-PPN: | 1666426768 |
| Verknüpfungen: | → Zeitschrift |
