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Verfasst von:Kriegsmann, Katharina [VerfasserIn]   i
 Kriegsmann, Mark [VerfasserIn]   i
 Cremer, Martin [VerfasserIn]   i
 Schmitt, Michael [VerfasserIn]   i
 Dreger, Peter [VerfasserIn]   i
 Goldschmidt, Hartmut [VerfasserIn]   i
 Müller-Tidow, Carsten [VerfasserIn]   i
 Hundemer, Michael [VerfasserIn]   i
Titel:Cell-based immunotherapy approaches for multiple myeloma
Verf.angabe:Katharina Kriegsmann, Mark Kriegsmann, Martin Cremer, Michael Schmitt, Peter Dreger, Hartmut Goldschmidt, Carsten Müller-Tidow and Michael Hundemer
Jahr:2019
Jahr des Originals:2018
Umfang:7 S.
Fussnoten:Published online: 6 December 2018 ; Gesehen am 31.05.2019
Titel Quelle:Enthalten in: British journal of cancer
Ort Quelle:Edinburgh : Nature Publ. Group, 1999
Jahr Quelle:2019
Band/Heft Quelle:120(2019), 1, Seite 38-44
ISSN Quelle:1532-1827
Abstract:Despite the arrival of novel therapies, multiple myeloma (MM) remains incurable and new treatment options are needed. Chimeric antigen receptor (CAR) T cells are genetically modified T cells that express a CAR directed against specific tumour antigens. CAR T cells are able to kill target tumour cells and may result in long-lasting immune responses in vivo. The rapid development of CAR technologies has led to clinical trials in haematological cancers including MM, and CAR T cells might evolve into a standard treatment in the next few years. Only small patient cohorts with relapsed or refractory disease have so far been investigated, but promising preliminary results with high response rates have been obtained in phase I clinical trials with B cell maturation antigen (BCMA), CD19, CD38 and κ-light-chain CAR T cells. Additional preclinical studies on CD38 and SLAMF7-CAR T cells in MM treatment yielded preclinical results that merit further investigation. Beyond the T cell approach, recent studies have focussed on CAR natural killer (NK) cells in order to increase the reactivity of these effector cells. Finally, to investigate the targeting of intracellular antigens, cellular therapies based on engineered T cell receptors (TCRs) are in development. In this review, we discuss results from preclinical and early-phase clinical trials testing the feasibility and safety of CAR T cell administration in MM, as well as early studies into approaches that utilise CAR NK cell and genetically modified TCRs.
DOI:doi:10.1038/s41416-018-0346-9
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1038/s41416-018-0346-9
 Volltext: https://www.nature.com/articles/s41416-018-0346-9
 DOI: https://doi.org/10.1038/s41416-018-0346-9
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1666431567
Verknüpfungen:→ Zeitschrift

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