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Verfasst von:Böcker, Arne Hendrik [VerfasserIn]   i
 Däschler, Simeon C. [VerfasserIn]   i
 Kneser, Ulrich [VerfasserIn]   i
 Harhaus-Wähner, Leila [VerfasserIn]   i
Titel:Relevance and recent developments of chitosan in peripheral nerve surgery
Verf.angabe:A. Boecker, S.C. Daeschler, U. Kneser and L. Harhaus
E-Jahr:2019
Jahr:04 April 2019
Fussnoten:Gesehen am 28.05.2019
Titel Quelle:Enthalten in: Frontiers in cellular neuroscience
Ort Quelle:Lausanne : Frontiers Research Foundation, 2007
Jahr Quelle:2019
Band/Heft Quelle:13(2019) Artikel-Nummer 104, 15 Seiten
ISSN Quelle:1662-5102
Abstract:Developments in tissue engineering lead to biomaterials with different supporting strategies to promote nerve regeneration. One promising material is the naturally occurring chitin derivate chitosan. Chitosan has become increasingly important in various tissue engineering approaches for peripheral nerve reconstruction, as it has demonstrated its potential to interact with regeneration associated cells and the neural microenvironment, leading to improved axonal regeneration and less neuroma formation. Moreover, the physiological properties of its polysaccharide structure provide safe biodegradation behavior in the absence of negative side effects or toxic metabolites. Beneficial interactions with Schwann cells, inducing differentiation of mesenchymal stromal cells to Schwann cell-like cells or creating supportive conditions during axonal recovery are only a small part of the effects of chitosan. As a result an extensive body of literature addresses a variety of experimental strategies for the different types of nerve lesions. The different concepts include chitosan nanofibers, hydrogels, hollow nerve tubes, nerve conduits with an inner chitosan layer as well as hybrid architectures containing collagen or polyglycolic acid nerve conduits. Furthermore, various cell seeding concepts have been introduced in the preclinical setting. First translational concepts with hollow tubes following nerve surgery already transferred the promising experimental approach into clinical practice. However, conclusive analyses of the available data and the proposed impact on the recovery process following nerve surgery are currently lacking. This review aims to give an overview on the physiologic properties of chitosan, to evaluate its effect on peripheral nerve regeneration and discuss the future translation into clinical practice.
DOI:doi:10.3389/fncel.2019.00104
URL:kostenfrei: Volltext: https://doi.org/10.3389/fncel.2019.00104
 kostenfrei: Volltext: https://www.frontiersin.org/articles/10.3389/fncel.2019.00104/full
 DOI: https://doi.org/10.3389/fncel.2019.00104
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Chitosan
 Material Properties
 Nerve surgery
 peripheral nerve regeneration/repair
 Translational Neuroscience
K10plus-PPN:1666434639
Verknüpfungen:→ Zeitschrift
 
 
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