| |  Online-Ressource |
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| Verfasst von: | Kälble, Florian [VerfasserIn]  |
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| | Mai, Charlotte [VerfasserIn] |
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| | Wagner, Miriam [VerfasserIn] |
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| | Schober, Linda [VerfasserIn] |
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| | Schaier, Matthias [VerfasserIn] |
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| | Zeier, Martin [VerfasserIn] |
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| | Spratte, Julia [VerfasserIn] |
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| | Fluhr, Herbert [VerfasserIn] |
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| | Steinborn-Kröhl, Andrea [VerfasserIn] |
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| Titel: | Aberrant ICOS+-T cell differentiation in women with spontaneous preterm labor |
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| Verf.angabe: | Florian Kälble, Charlotte Mai, Miriam Wagner, Linda Schober, Matthias Schaier, Martin Zeier, Julia Spratte, Herbert Fluhr, Andrea Steinborn |
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| E-Jahr: | 2016 |
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| Jahr: | 21 September 2016 |
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| Umfang: | 11 S. |
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| Fussnoten: | Im Titel ist "+" hochgestellt ; Gesehen am 29.05.2019 |
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| Titel Quelle: | Enthalten in: American journal of reproductive immunology |
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| Ort Quelle: | Oxford : Wiley Blackwell, 1980 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 76(2016), 5, Seite 415-425 |
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| ISSN Quelle: | 1600-0897 |
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| Abstract: | Problem Recent studies revealed appropriate differentiation of recent thymic emigrant (RTE)-regulatory T cells (Tregs) to be crucial for maintaining healthy pregnancy. Currently, the role of responder T cells (Tresps) is not known. Method of study Six-color flow cytometric analysis was used to detect differences in the differentiation of highly proliferative inducible co-stimulatory (ICOS)+-RTE-Tregs/Tresps and apoptosis-sensitive ICOS−-RTE-Tregs/Tresps into mature naïve (MN)-, CD31+-memory and CD31−-memory Tregs/Tresps in women with spontaneous preterm labor (sPL) compared to healthy pregnancy. Results Healthy pregnancy was characterized by an increased differentiation of ICOS+- and ICOS−-RTE-Tregs, as well as ICOS+-RTE-Tresps via CD31+-memory Tregs/Tresps into CD31−-memory Tregs/Tresps. Women with sPL showed an early interruption of RTE-Treg/Tresp differentiation. Instead, ICOS+-MN-Tresps and partly ICOS−-MN-Tregs differentiated into CD31−-memory Tregs/Tresps, causing a significant reduction of both ICOS+-Tregs and ICOS+-Tresps, but an increase of ICOS−-Tresps within total CD4+-T-helper cells. Conclusion Aberrant differentiation of ICOS+-T cells is associated with sPL. |
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| DOI: | doi:10.1111/aji.12565 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1111/aji.12565 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/aji.12565 |
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| | DOI: https://doi.org/10.1111/aji.12565 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | cervical insufficiency |
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| | immunosuppression |
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| | pregnancy |
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| | preterm labor |
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| | preterm premature rupture of fetal membranes |
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| | regulatory T cells |
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| K10plus-PPN: | 1666477877 |
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| Verknüpfungen: | → Zeitschrift |
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Aberrant ICOS+-T cell differentiation in women with spontaneous preterm labor / Kälble, Florian [VerfasserIn]; 21 September 2016 (Online-Ressource)
