Probing molecular forces in multi-component physiological membranes

• Verfasst von: Ray, Arjun [VerfasserIn]
• Verfasst von: Gräter, Frauke [VerfasserIn]
• Verfasst von: Thukral, Lipi [VerfasserIn]
• Titel: Probing molecular forces in multi-component physiological membranes
• Verf.angabe: Arjun Ray, Frauke Gräter and Lipi Thukral
• Jahr: 2018
• Jahr des Originals: 2017
• Umfang: 8 S.
• Fussnoten: First published on 27 Nov 2017 ; Gesehen am 29.05.2019
• Titel Quelle: Enthalten in: Physical chemistry, chemical physics
• Ort Quelle: Cambridge : RSC Publ., 1999
• Jahr Quelle: 2018
• Band/Heft Quelle: 20(2018), 4, Seite 2155-2161
• ISSN Quelle: 1463-9084
• DOI: doi:10.1039/C7CP05981G
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1666527955

Abstract

Biological membranes are remarkably heterogeneous, composed of diverse lipid mixtures with distinct chemical structure and composition. By combining molecular dynamics simulations and the newly developed Lipid-Force Distribution Analysis (L-FDA), we explore force transmission in complex multi-component membrane models mimicking eukaryotic organelles. We found that the chemical-moiety based segmentation at membrane interfaces revealed a distinctive distribution of bonded and non-bonded forces in diverse membrane environment. Our molecular stress analysis could have far-reaching implications in describing the relationship between membrane mechanical properties and functional states of chemically distinct lipids.