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Status: Bibliographieeintrag

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Verfasst von:Westhauser, Fabian [VerfasserIn]   i
 Senger, Anne-Sophie [VerfasserIn]   i
 Obert, David Peter [VerfasserIn]   i
 Ciraldo, Francesca E. [VerfasserIn]   i
 Schuhladen, Katharina [VerfasserIn]   i
 Schmidmaier, Gerhard [VerfasserIn]   i
 Moghaddam-Alvandi, Arash [VerfasserIn]   i
 Boccaccini, Aldo R. [VerfasserIn]   i
Titel:Gelatin coating increases in vivo bone formation capacity of three-dimensional 45S5 bioactive glass-based crystalline scaffolds
Verf.angabe:Fabian Westhauser, Anne-Sophie Senger, David Obert, Francesca E. Ciraldo, Katharina Schuhladen, Gerhard Schmidmaier, Arash Moghaddam, Aldo R. Boccaccini
Jahr:2019
Jahr des Originals:2018
Umfang:12 S.
Fussnoten:First published: 07 December 2018 ; Gesehen am 29.05.2019
Titel Quelle:Enthalten in: Journal of tissue engineering and regenerative medicine
Ort Quelle:Hoboken, NJ [u.a.] : Wiley, 2007
Jahr Quelle:2019
Band/Heft Quelle:13(2019), 2, Seite 179-190
ISSN Quelle:1932-7005
Abstract:Recent studies have demonstrated that surface characteristics, porosity, and mechanical strength of three-dimensional 45S5-type bioactive glass (BG)-based scaffolds are directly correlated with osteogenic properties. Three-dimensional BG-based scaffolds obtained from maritime natural sponges (MNSs) as sacrificial templates exhibit the required morphological properties; however, no in vivo data about the osteogenic features are available. In this study, uncoated (Group A) and gelatin-coated (Group B) crystalline MNS-obtained BG-based scaffolds were evaluated mechanically and seeded with human mesenchymal stem cells prior to subcutaneous implantation in immunodeficient mice. Before implantation and after explantation, micro-computed tomography scans were conducted, and scaffolds were finally subjected to histomorphometry. Scaffolds of both groups showed bone formation. However, Group B scaffolds performed distinctly better as indicated by a significant increase in scaffold volume (8.95%, p = 0.039) over the implantation period compared with a nonsignificant increase of 5.26% in Group A scaffolds in micro-computed tomography analysis. Furthermore, percentage bone area was 10.33% (±1.18%) in the Group B scaffolds, which was significantly (p = 0.007) higher compared with the 8.53% (±0.77%) in the Group A scaffolds in histomorphometry. Compressive strength was enhanced significantly by gelatin coating (9 ± 2 vs. 4 ± 1 MPa; p = 0.029). The presence of gelatin on the remnant parts was verified by scanning electron microscopy and X-ray spectroscopy, demonstrating the coatings' resilience. MNS-obtained BG-based scaffolds were thus confirmed to exhibit osteogenic properties in vivo that can significantly be enhanced by gelatin coating.
DOI:doi:10.1002/term.2780
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1002/term.2780
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/term.2780
 DOI: https://doi.org/10.1002/term.2780
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:bioactive glass
 bone formation
 gelatin coating
 human mesenchymal stem cells
 in vivo
 maritime sponge
 micro-computed tomography
 tissue engineering
K10plus-PPN:1666536016
Verknüpfungen:→ Zeitschrift

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