Pre-diagnostic derivatives of reactive oxygen metabolites and the occurrence of lung, colorectal, breast and prostate cancer

• Verfasst von: Gao, Xin [VerfasserIn]
• Verfasst von: Xuan, Yang [VerfasserIn]
• Verfasst von: Anusruti, Ankita [VerfasserIn]
• Verfasst von: Brenner, Hermann [VerfasserIn]
• Verfasst von: Schöttker, Ben [VerfasserIn]
• Titel: Pre-diagnostic derivatives of reactive oxygen metabolites and the occurrence of lung, colorectal, breast and prostate cancer
• Titelzusatz: an individual participant data meta-analysis of two large population-based studies
• Verf.angabe: Xīn Gào, Tom Wilsgaard, Eugène HJM Jansen, Bernd Holleczek, Yan Zhang, Yang Xuan, Ankita Anusruti, Hermann Brenner and Ben Schöttker
• Jahr: 2019
• Jahr des Originals: 2018
• Umfang: 9 S.
• Teil: volume:145
• Teil: year:2019
• Teil: number:1
• Teil: pages:49-57
• Teil: extent:9
• Fussnoten: Gesehen am 31.05.2019 ; First published: 18 December 2018
• Titel Quelle: Enthalten in: International journal of cancer
• Ort Quelle: Bognor Regis : Wiley-Liss, 1966
• Jahr Quelle: 2019
• Band/Heft Quelle: 145(2019), 1, Seite 49-57
• ISSN Quelle: 1097-0215
• DOI: doi:10.1002/ijc.32073
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: breast cancer
• Sach-SW: cohort study
• Sach-SW: colorectal cancer
• Sach-SW: d-ROM
• Sach-SW: lung cancer
• Sach-SW: oxidative stress
• Sach-SW: prostate cancer
• K10plus-PPN: 166657886X

Abstract

Oxidative stress may be involved in carcinogenesis and biomarkers of oxidative stress like derivatives of reactive oxygen metabolites (d-ROM) may be useful for cancer prediction. However, no previous study assessed the association of pre-diagnostic d-ROM measurements with cancer incidence. We measured serum d-ROM levels in a cohort sample of n = 4,345 participants of the German ESTHER study and in a case-cohort sample of the Norwegian Tromsø study (cancer cases: n = 941; subcohort: n = 1,000). Moreover, d-ROM was repeatedly measured at follow-ups of both studies. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were derived by (weighted) multivariable-adjusted Cox regression with time-dependent modeling of d-ROM levels for incident lung, colorectal, breast and prostate cancer. Individual study results were pooled by random effects meta-analysis. The HRs (95% CI) for comparison of top and bottom d-ROM tertile were statistically significant for lung (1.90 [1.25-2.89]), colorectal (1.70 [1.15-2.51]) and breast cancer incidence (1.45 [1.01-2.09]) but not for prostate cancer incidence (1.20 [0.84-1.72]). In conclusion, this individual participant data meta-analysis of two large population-based cohort studies with repeated d-ROM measurements yielded evidence for an involvement of high oxidative stress in carcinogenesis. Given the observed associations of pre-diagnostic d-ROM measurements with lung, colorectal and breast cancer incidence, subjects with increased serum d-ROM levels should be recommended to reduce these levels by lifestyle changes including smoking cessation, a healthy diet and an increase in physical activity.