Robust and accurate quantification of biomarkers of immune cells in lung cancer micro-environment using deep convolutional neural networks

• Verfasst von: Aprupe, Lilija [VerfasserIn]
• Verfasst von: Brinker, Titus Josef [VerfasserIn]
• Verfasst von: Grabe, Niels [VerfasserIn]
• Titel: Robust and accurate quantification of biomarkers of immune cells in lung cancer micro-environment using deep convolutional neural networks
• Verf.angabe: Lilija Aprupe, Geert Litjens, Titus J. Brinker, Jeroen van der Laak, Niels Grabe
• E-Jahr: 2019
• Jahr: April 10, 2019
• Umfang: 16 S.
• Fussnoten: Gesehen am 03.06.2019
• Titel Quelle: Enthalten in: PeerJ
• Ort Quelle: London [u.a.] : PeerJ, Inc., 2013
• Jahr Quelle: 2019
• Band/Heft Quelle: 7(2019) Artikel-Nummer e6335, 16 Seiten
• ISSN Quelle: 2167-8359
• DOI: doi:10.7717/peerj.6335
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Biomarker quantification
• Sach-SW: Cancer micro-environment
• Sach-SW: Deep learning
• Sach-SW: Immune cells
• Sach-SW: Lung cancer
• K10plus-PPN: 1666612391

Abstract

Recent years have seen a growing awareness of the role the immune system plays in successful cancer treatment, especially in novel therapies like immunotherapy. The characterization of the immunological composition of tumors and their micro-environment is thus becoming a necessity. In this paper we introduce a deep learning-based immune cell detection and quantification method, which is based on supervised learning, i.e., the input data for training comprises labeled images. Our approach objectively deals with staining variation and staining artifacts in immunohistochemically stained lung cancer tissue and is as precise as humans. This is evidenced by the low cell count difference to humans of 0.033 cells on average. This method, which is based on convolutional neural networks, has the potential to provide a new quantitative basis for research on immunotherapy.