Status: Bibliographieeintrag
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| Verfasst von: | Villani, Ambra [VerfasserIn]  |
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| | Benjaminsen, Jørgen [VerfasserIn] |
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| | Hartmann, Jonas [VerfasserIn] |
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| Titel: | Clearance by microglia depends on packaging of phagosomes into a unique cellular compartment |
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| Verf.angabe: | Ambra Villani, Jørgen Benjaminsen, Christian Moritz, Katrin Henke, Jonas Hartmann, Nils Norlin, Kerstin Richter, Nicole L. Schieber, Tilman Franke, Yannick Schwab, Francesca Peri |
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| E-Jahr: | 2019 |
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| Jahr: | April 8, 2019 |
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| Umfang: | 20 S. |
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| Fussnoten: | Gesehen am 03.06.2019 |
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| Titel Quelle: | Enthalten in: Developmental cell |
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| Ort Quelle: | Cambridge, Mass. : Cell Press, 2001 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 49(2019), 1, Seite 77-88 |
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| ISSN Quelle: | 1878-1551 |
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| Abstract: | Phagocytic immune cells such as microglia can engulf and process pathogens and dying cells with high efficiency while still maintaining their dynamic behavior and morphology. Effective intracellular processing of ingested cells is likely to be crucial for microglial function, but the underlying cellular mechanisms are poorly understood. Using both living fish embryos and mammalian macrophages, we show that processing depends on the shrinkage and packaging of phagosomes into a unique cellular compartment, the gastrosome, with distinct molecular and ultra-structural characteristics. Loss of the transporter Slc37a2 blocks phagosomal shrinkage, resulting in the expansion of the gastrosome and the dramatic bloating of the cell. This, in turn, affects the ability of microglia to phagocytose and migrate toward brain injuries. Thus, this work identifies a conserved crucial step in the phagocytic pathway of immune cells and provides a potential entry point for manipulating their behavior in development and disease. |
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| DOI: | doi:10.1016/j.devcel.2019.02.014 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1016/j.devcel.2019.02.014 |
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| | DOI: https://doi.org/10.1016/j.devcel.2019.02.014 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | apoptotic cell clearance |
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| | brain development |
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| | efferocytosis |
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| | macrophage |
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| | microglia |
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| | neuronal cell death |
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| | neuronal immunity |
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| | phagocytosis |
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| | slc37a2 |
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| | zebrafish |
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| K10plus-PPN: | 1666633496 |
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| Verknüpfungen: | → Zeitschrift |
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Clearance by microglia depends on packaging of phagosomes into a unique cellular compartment / Villani, Ambra [VerfasserIn]; April 8, 2019 (Online-Ressource)
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