Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Combs, Stephanie [VerfasserIn]   i
 Adeberg, Sebastian [VerfasserIn]   i
 Bougatf, Nina [VerfasserIn]   i
 Debus, Jürgen [VerfasserIn]   i
Titel:Re-irradiation of recurrent gliomas
Titelzusatz:pooled analysis and validation of an established prognostic score—report of the Radiation Oncology Group (ROG) of the German Cancer Consortium (DKTK)
Verf.angabe:Stephanie E. Combs, Maximilian Niyazi, Sebastian Adeberg, Nina Bougatf, David Kaul, Daniel F. Fleischmann, Arne Gruen, Emmanouil Fokas, Claus M. Rödel, Franziska Eckert, Frank Paulsen, Oliver Oehlke, Anca-Ligia Grosu, Annekatrin Seidlitz, Annika Lattermann, Mechthild Krause, Michael Baumann, Maja Guberina, Martin Stuschke, Volker Budach, Claus Belka, Jürgen Debus, & Kerstin A. Kessel
E-Jahr:2018
Jahr:23 March 2018
Umfang:8 S.
Illustrationen:Diagramme
Fussnoten:Gesehen am 05.06.2019
Titel Quelle:Enthalten in: Cancer medicine
Ort Quelle:Hoboken, NJ : Wiley, 2012
Jahr Quelle:2018
Band/Heft Quelle:7(2018), 5, Seite 1742-1749
ISSN Quelle:2045-7634
Abstract:The heterogeneity of high-grade glioma recurrences remains an ongoing challenge for the interdisciplinary neurooncology team. Response to re-irradiation (re-RT) is heterogeneous, and survival data depend on prognostic factors such as tumor volume, primary histology, age, the possibility of reresection, or time between primary diagnosis and initial RT and re-RT. In the present pooled analysis, we gathered data from radiooncology centers of the DKTK Consortium and used it to validate the established prognostic score by Combs et al. and its modification by Kessel et al. Data consisted of a large independent, multicenter cohort of 565 high-grade glioma patients treated with re-RT from 1997 to 2016 and a median dose of 36 Gy. Primary RT was between 1986 and 2015 with a median dose of 60 Gy. Median age was 54 years; median follow-up was 7.1 months. Median OS after re-RT was 7.5, 9.5, and 13.8 months for WHO IV, III, and I/II gliomas, respectively. All six prognostic factors were tested for their significance on OS. Aside from the time from primary RT to re-RT (P = 0.074) and the reresection status (P = 0.101), all factors (primary histology, age, KPS, and tumor volume) were significant. Both the original and new score showed a highly significant influence on survival with P < 0.001. Both prognostic scores successfully predict survival after re-RT and can easily be applied in the routine clinical workflow. Now, further prognostic features need to be found to even improve treatment decisions regarding neurooncological interventions for recurrent glioma patients.
DOI:doi:10.1002/cam4.1425
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1002/cam4.1425
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/cam4.1425
 DOI: https://doi.org/10.1002/cam4.1425
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Outcome
 prognostic score
 re-irradiation
 recurrent glioma
K10plus-PPN:1666814652
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68396490   QR-Code
zum Seitenanfang