Investigation on potential associations of oxidatively generated DNA/RNA damage with lung, colorectal, breast, prostate and total cancer incidence

• Verfasst von: Gao, Xin [VerfasserIn]
• Verfasst von: Holleczek, Bernd [VerfasserIn]
• Verfasst von: Cuk, Katarina [VerfasserIn]
• Verfasst von: Zhang, Yan [VerfasserIn]
• Verfasst von: Anusruti, Ankita [VerfasserIn]
• Verfasst von: Xuan, Yang [VerfasserIn]
• Verfasst von: Brenner, Hermann [VerfasserIn]
• Verfasst von: Schöttker, Ben [VerfasserIn]
• Titel: Investigation on potential associations of oxidatively generated DNA/RNA damage with lung, colorectal, breast, prostate and total cancer incidence
• Verf.angabe: Xīn Gào, Bernd Holleczek, Katarina Cuk, Yan Zhang, Ankita Anusruti, Yang Xuan, Yiwei Xu, Hermann Brenner & Ben Schöttker
• E-Jahr: 2019
• Jahr: 08 May 2019
• Umfang: 9 S.
• Teil: volume:9
• Teil: year:2019
• Teil: extent:9
• Fussnoten: Gesehen am 05.06.2019
• Titel Quelle: Enthalten in: Scientific reports
• Ort Quelle: [London] : Macmillan Publishers Limited, part of Springer Nature, 2011
• Jahr Quelle: 2019
• Band/Heft Quelle: 9(2019) Artikel-Nummer 7109, 9 Seiten
• ISSN Quelle: 2045-2322
• DOI: doi:10.1038/s41598-019-42596-x
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1666846333

Abstract

Oxidative stress has been linked to cancer development in previous studies. However, the association between pre-diagnostic oxidatively generated DNA/RNA damage levels and incident cancer has rarely been investigated. Urinary oxidized guanine/guanosine (OxGua) concentrations, including 8-hydroxy-2′-deoxyguanosine, were assessed in 8,793 older adults in a population-based German cohort. 1,540 incident cancer cases, including 207 lung, 196 colorectal, 218 breast and 245 prostate cancer cases were diagnosed during over 14 years of follow-up. Associations of OxGua levels with cancer outcomes were not observed in the total population in multi-variable adjusted Cox regression models. However, in subgroup analyses, colorectal cancer incidence increased by 8%, 9% and 8% with one standard deviation increase in OxGua levels among current non-smokers, female and non-obese participants, respectively. Additionally, among non-smokers, overall and prostate cancer incidences statistically significantly increased by 5% and 13% per 1 standard deviation increase in OxGua levels, respectively. In contrast, OxGua levels were inversely associated with the risk of prostate cancer among current smokers. However, none of the subgroup analyses had p-values below a threshold for statistical significance after correction for multiple testing. Thus, results need to be validated in further studies. There might be a pattern that oxidatively generated DNA/RNA damage is a weak cancer risk factor in the absence of other strong risk factors, such as smoking, obesity and male sex.