Status: Bibliographieeintrag
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| |  Online-Ressource |
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| Verfasst von: | Peterfi, Lehel [VerfasserIn]  |
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| | Yusenko, Maria [VerfasserIn] |
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| | Kovacs, Gyula [VerfasserIn] |
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| Titel: | IL6 shapes an inflammatory microenvironment and triggers the development of unique types of cancer in end-stage kidney |
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| Verf.angabe: | Lehel Peterfi, Maria V. Yusenko, Gyula Kovacs |
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| Jahr: | 2019 |
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| Umfang: | 6 S. |
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| Fussnoten: | Gesehen am 06.06.2019 |
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| Titel Quelle: | Enthalten in: Anticancer research |
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| Ort Quelle: | Attiki, 2004 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 39(2019), 4, Seite 1869-1874 |
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| ISSN Quelle: | 1791-7530 |
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| Abstract: | BACKGROUND/AIM: Chronic inflammation in end-stage kidney is associated with the development of pre-neoplastic lesions and renal cell tumors. The aim of this study was to clarify the role of the inflammatory microenvironment in this process. - MATERIALS AND METHODS: We used representative microscopic slides from 11 end stage-kidneys containing pre-neoplastic lesions and tumors and applied immunohistochemistry to detect IL-6, SAA1 and LBP expression. We also applied array-based comparative genomic hybridization (CGH) analysis to detect genomic changes in tumor cells. - RESULTS: We identified strong expression of IL6, LBP and SAA1 in activated stromal fibroblasts, in proliferating epithelial and tumor cells. Array CGH detected unusual genomic changes in tumor cells. - CONCLUSION: Our data indicate that expression of IL6, acute phase protein SAA1 and LBP maintain a long-lasting inflammatory microenvironment that leads to remodeling of end-stage kidneys and the development of unique types of renal cell tumors. |
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| DOI: | doi:10.21873/anticanres.13294 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.21873/anticanres.13294 |
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| | DOI: https://doi.org/10.21873/anticanres.13294 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Acute-Phase Proteins |
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| | Adult |
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| | Aged |
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| | Carrier Proteins |
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| | Cell Proliferation |
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| | Comparative Genomic Hybridization |
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| | End stage renal disease |
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| | Epithelial Cells |
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| | Female |
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| | Fibroblasts |
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| | Humans |
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| | IL6 |
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| | Immunohistochemistry |
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| | Inflammation Mediators |
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| | Interleukin-6 |
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| | Kidney |
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| | Kidney Failure, Chronic |
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| | Kidney Neoplasms |
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| | LBP |
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| | Male |
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| | Membrane Glycoproteins |
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| | microenvironment |
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| | Middle Aged |
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| | Precancerous Conditions |
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| | SAA1 |
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| | Serum Amyloid A Protein |
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| | Stromal Cells |
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| | tumor development |
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| | Tumor Microenvironment |
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| K10plus-PPN: | 1666940267 |
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| Verknüpfungen: | → Zeitschrift |
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IL6 shapes an inflammatory microenvironment and triggers the development of unique types of cancer in end-stage kidney / Peterfi, Lehel [VerfasserIn]; 2019 (Online-Ressource)
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