Species-conserved reconfigurations of brain network topology induced by ketamine

• Verfasst von: Becker, Robert [VerfasserIn]
• Verfasst von: Sartorius, Alexander [VerfasserIn]
• Verfasst von: Meyer-Lindenberg, Andreas [VerfasserIn]
• Titel: Species-conserved reconfigurations of brain network topology induced by ketamine
• Verf.angabe: R. Becker, U. Braun, A.J. Schwarz, N. Gass, J.I. Schweiger, W. Weber-Fahr, E. Schenker, M. Spedding, C. Clemm von Hohenberg, C. Risterucci, Z. Zang, O. Grimm, H. Tost, A. Sartorius and A. Meyer-Lindenberg
• E-Jahr: 2016
• Jahr: 19 April 2016
• Umfang: 7 S.
• Fussnoten: Gesehen am 07.06.2019
• Titel Quelle: Enthalten in: Translational Psychiatry
• Ort Quelle: London : Nature Publishing Group, 2011
• Jahr Quelle: 2016
• Band/Heft Quelle: 6(2016,4) Artikel-Nummer e786, 7 Seiten
• ISSN Quelle: 2158-3188
• DOI: doi:10.1038/tp.2016.53
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1667001353

Abstract

Species-conserved (intermediate) phenotypes that can be quantified and compared across species offer important advantages for translational research and drug discovery. Here, we investigate the utility of network science methods to assess the pharmacological alterations of the large-scale architecture of brain networks in rats and humans. In a double-blind, placebo-controlled, cross-over study in humans and a placebo-controlled two-group study in rats, we demonstrate that the application of ketamine leads to a topological reconfiguration of large-scale brain networks towards less-integrated and more-segregated information processing in both the species. As these alterations are opposed to those commonly observed in patients suffering from depression, they might indicate systems-level correlates of the antidepressant effect of ketamine.