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Status: Bibliographieeintrag

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Verfasst von:Felcht, Moritz [VerfasserIn]   i
 Klemke, Claus-Detlev [VerfasserIn]   i
 Nicolay, Jan Peter [VerfasserIn]   i
 Weiß, Christel [VerfasserIn]   i
 Géraud, Cyrill [VerfasserIn]   i
 Marx, Alexander [VerfasserIn]   i
 Goerdt, Sergij [VerfasserIn]   i
Titel:Primary cutaneous diffuse large B-cell lymphoma, NOS and leg type
Titelzusatz:Clinical, morphologic and prognostic differences
Verf.angabe:Moritz Felcht, Claus-Detlev Klemke, Jan Peter Nicolay, Christel Weiss, Chalid Assaf, Marion Wobser, Max Schlaak, Uwe Hillen, Rose Moritz, Iliana Tantcheva‐Poor, Dorothee Nashan, Marc Beyer, Edgar Dippel, Cornelia Sigrid Lissi Müller, Michael Max Sachse, Frank Meiss, Cyrill Géraud, Alexander Marx, Sergij Goerdt, Eva Geissinger, Werner Kempf
E-Jahr:2019
Jahr:09 March 2019
Umfang:11 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 12.06.2019
Titel Quelle:Enthalten in: Deutsche Dermatologische GesellschaftJournal der Deutschen Dermatologischen Gesellschaft
Ort Quelle:Berlin : Wiley-Blackwell, 2003
Jahr Quelle:2019
Band/Heft Quelle:17(2019), 3, Seite 275-285
ISSN Quelle:1610-0387
Abstract:Background and objectives Primary cutaneous diffuse large B-cell lymphoma, NOS (PCLBCL/NOS) is a rare PCLBCL. Only few data are available for this tumor. The aim of this study was to identify clinical and/or immunohistochemical markers (in addition to Bcl-2) that characterize PCLBCL/NOS, assist in differentiating it from PCLBCL, leg type (PCLBCL/LT) and help to assess the clinical course/prognosis. Patients and methods Bcl-2- PCLBCL/NOS) cases (n = 14 were compared with Bcl-2+ PCLBCL/LT cases (n = 29). Results PCLBCL/NOS patients were younger, predominantly male and had better survival rates than patients with PCLBCL/LT. Patients with PCLBCL/NOS presented more often with larger plaques limited to one or two contiguous body regions, whereas PCLBCL/LT cases often presented with disseminated lesions. Neoplastic cells had a higher proliferation rate (Ki67) in PCLBCL/LT patients. The tumor microenvironment of PCLBCL/NOS had a more prominent CD3+ infiltrate. Overall survival data for the whole cohort (n = 37) revealed that female gender and Bcl-2 expression correlated with a worse survival rate. Bcl-6 expression and centroblastic subtype correlated with better outcomes. None of the other markers studied (e.g. GCB/non-GCB subtype) correlated with survival rate. Conclusions PCLBCL/NOS and PCLBCL/LT differ in their clinical behavior and outcomes. Bcl-2 still seems to be the best marker for discriminating between these two subgroups. Bcl-2, female gender and Bcl-6 represent prognostic markers for PCLBCL.
DOI:doi:10.1111/ddg.13773
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1111/ddg.13773
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/ddg.13773
 DOI: https://doi.org/10.1111/ddg.13773
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1667283103
Verknüpfungen:→ Zeitschrift

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