| |  Online-Ressource |
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| Verfasst von: | Popp, Henning [VerfasserIn]  |
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| | Flach, Johanna [VerfasserIn] |
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| | Brendel, Susanne [VerfasserIn] |
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| | Ruppenthal, Sabrina [VerfasserIn] |
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| | Kleiner, Helga [VerfasserIn] |
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| | Seifarth, Wolfgang [VerfasserIn] |
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| | Schneider, Sven [VerfasserIn] |
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| | Schulze, Torsten [VerfasserIn] |
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| | Weiß, Christel [VerfasserIn] |
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| | Wenz, Frederik [VerfasserIn] |
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| | Hofmann, Wolf-Karsten [VerfasserIn] |
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| | Fabarius, Alice [VerfasserIn] |
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| Titel: | Accumulation of DNA damage and alteration of the DNA damage response in monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia |
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| Verf.angabe: | Henning D. Popp, Johanna Flach, Susanne Brendel, Sabrina Ruppenthal, Helga Kleiner, Wolfgang Seifarth, Sven Schneider, Torsten J. Schulze, Christel Weiss, Frederik Wenz, Wolf-Karsten Hofmann, Alice Fabarius |
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| Jahr: | 2019 |
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| Umfang: | 10 S. |
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| Fussnoten: | Published online: 31 October 2018 ; Gesehen am 13.06.2019 |
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| Titel Quelle: | Enthalten in: Leukemia and lymphoma |
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| Ort Quelle: | London [u.a.] : Taylor & Francis Group, 1989 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 60(2019), 3, Seite 795-804 |
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| ISSN Quelle: | 1029-2403 |
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| Abstract: | Accumulation of DNA damage and alteration of the DNA damage response (DDR) are critical features of genetic instability that is presumed to be implicated in the pathogenesis of monoclonal B-cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL). Here, we show increased numbers of γH2AX foci, a marker of DNA double-strand breaks (DSB), in CD19+ cells of CLL patients as compared to CD19+ cells of MBL patients and healthy individuals. Furthermore, numerous γH2AX/53BP1 foci in CLL cells suggest activation of error-prone non-homologous end-joining repair mechanisms. Signatures of DDR proteins further indicate alterations of the DDR in CLL in contrast to a largely regular activation in MBL and healthy controls. In summary, our results provide evidence for the stepwise accumulation of DNA damage in the progression of MBL towards CLL and suggest increased DNA damage, error-prone DNA repair and altered DDR signaling to be critical mechanisms of clonal evolution in MBL and CLL. |
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| DOI: | doi:10.1080/10428194.2018.1498494 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1080/10428194.2018.1498494 |
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| | DOI: https://doi.org/10.1080/10428194.2018.1498494 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | chronic lymphocytic leukemia |
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| | DNA damage response |
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| | DNA double-strand breaks |
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| | genetic instability |
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| | Monoclonal B-cell lymphocytosis |
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| K10plus-PPN: | 1667354299 |
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| Verknüpfungen: | → Zeitschrift |
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Accumulation of DNA damage and alteration of the DNA damage response in monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia / Popp, Henning [VerfasserIn]; 2019 (Online-Ressource)
