Virus entry and its inhibition to prevent and treat hepatitis B and hepatitis D virus infections

• Verfasst von: Tu, Thomas [VerfasserIn]
• Verfasst von: Urban, Stephan [VerfasserIn]
• Titel: Virus entry and its inhibition to prevent and treat hepatitis B and hepatitis D virus infections
• Verf.angabe: Thomas Tu, Stephan Urban
• E-Jahr: 2018
• Jahr: 15th May 2018
• Umfang: 12 S.
• Fussnoten: Gesehen am 14.06.2019
• Titel Quelle: Enthalten in: Current opinion in virology
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 2011
• Jahr Quelle: 2018
• Band/Heft Quelle: 30(2018), Seite 68-79
• ISSN Quelle: 1879-6265
• DOI: doi:10.1016/j.coviro.2018.04.004
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1667475797

Abstract

While chronic infection with the human hepatitis B virus (HBV) and hepatitis delta virus (HDV) inflict major health burdens worldwide, current therapies cannot cure patients. One possible novel approach is blocking virus entry to prevent the establishment of infection in naïve hepatocytes. As HBV and HDV use identical viral envelope proteins and the same entry mechanisms, such a strategy would target both viruses. Entry inhibitors (e.g. neutralizing antibodies) have been relegated to the limited role of prophylaxis. However, recent clinical data and infection studies show that new viral entry inhibitors could play a major role in eliminating intrahepatic HBV/HDV genomes. We highlight the consequences on viral persistence after preventing virus entry and the therapeutic benefits entry inhibitors could achieve.