Minoxidil for treatment of resistant hypertension in chronic kidney disease

• Verfasst von: Mundt, Heiko [VerfasserIn]
• Verfasst von: Lammert, Alexander [VerfasserIn]
• Verfasst von: Krämer, Bernhard [VerfasserIn]
• Verfasst von: Birck, Rainer [VerfasserIn]
• Verfasst von: Benck, Urs Tobias [VerfasserIn]
• Titel: Minoxidil for treatment of resistant hypertension in chronic kidney disease
• Titelzusatz: a retrospective cohort analysis
• Verf.angabe: Heiko M. Mundt, MD, Matthias Matenaer, Cand.Med, Alexander Lammert, MD, Uwe Göttmann, MD, Bernhard K. Krämer, MD, Rainer Birck, MD, Urs Benck, MD
• E-Jahr: 2016
• Jahr: 01 June 2016
• Umfang: 6 S.
• Fussnoten: Gesehen am 17.06.2019
• Titel Quelle: Enthalten in: The journal of clinical hypertension
• Ort Quelle: Hoboken, NJ : Wiley, 2001
• Jahr Quelle: 2016
• Band/Heft Quelle: 18(2016), 11, Seite 1162-1167
• ISSN Quelle: 1751-7176
• DOI: doi:10.1111/jch.12847
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1667510355

Abstract

Resistant hypertension is still a challenge and reserve antihypertensive agents are often necessary to achieve blood pressure control. One reserve antihypertensive is minoxidil, a direct vasodilator that is known for its strong blood pressure-lowering effect, but contemporary studies are sparse. The authors retrospectively analyzed 54 inpatients with uncontrolled hypertension despite the combined use of current antihypertensive agents. To investigate the effect of minoxidil when added to other antihypertensive agents, blood pressure was evaluated at the time minoxidil treatment was initiated and at discharge. Minoxidil treatment was associated with a significant reduction in blood pressure from 162.4±15.1/83.2±12.7 mm Hg to 135.8±12.2/72.8±6.9 mm Hg (P<.0001). This effect was sustained across all analyzed subgroups. Although the well-known adverse events of minoxidil limit its widespread use, these data show that minoxidil as a reserve antihypertensive agent still has a niche indication in the particular subgroup of patients with treatment-resistant or uncontrolled hypertension.