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Verfasst von:Förster, Alex [VerfasserIn]   i
 Wenz, Holger [VerfasserIn]   i
 Böhme, Johannes [VerfasserIn]   i
 Al-Zghloul, Mansour [VerfasserIn]   i
 Groden, Christoph [VerfasserIn]   i
Titel:Hyperintense acute reperfusion marker on FLAIR in posterior circulation infarction
Verf.angabe:Alex Förster, Holger Wenz, Johannes Böhme, Mansour Al-Zghloul, Christoph Groden
E-Jahr:2016
Jahr:June 21, 2016
Umfang:8 S.
Fussnoten:Gesehen am 17.06.2019
Titel Quelle:Enthalten in: PLOS ONE
Ort Quelle:San Francisco, California, US : PLOS, 2006
Jahr Quelle:2016
Band/Heft Quelle:11(2016,6) Artikel-Nummer e0157738, 8 Seiten
ISSN Quelle:1932-6203
Abstract:Purpose In the present study, we aimed to investigate the frequency of blood brain barrier injury in posterior circulation infarction as demonstrated by the hyperintense acute reperfusion marker (HARM) on fluid attenuated inversion recovery images (FLAIR). Methods From a MRI report database we identified patients with posterior circulation infarction who underwent MRI, including perfusion-weighted images (PWI), within 12 hours after onset and follow-up MRI within 24 hours and analyzed diffusion-weighted images (DWI), PWI, FLAIR, and MR angiography (MRA). On FLAIR images, the presence of HARM was noted by using pre-specified criteria (focal enhancement in the subarachnoid space and/or the ventricles). Results Overall 16 patients (median age of patients 68.5 (IQR 55.5-82.75) years) with posterior circulation infarction were included. Of these, 13 (81.3%) demonstrated PCA occlusion, and 3 (18.7%) patients BA occlusion on MRA. Initial DWI demonstrated ischemic lesions in the thalamus (68.8%), splenium (18.8%), hippocampus (75%), occipital lobe (81.3%), mesencephalon (18.8%), pons (18.8%), and cerebellum (50%). On follow-up MRA recanalization was noted in 10 (62.5%) patients. On follow-up FLAIR images, HARM was observed in 8 (50%) patients. In all of these, HARM was detected remote from the acute ischemic lesion. HARM was more frequently observed in patients with vessel recanalization (p = 0.04), minor infarction growth (p = 0.01), and smaller ischemic lesions on follow-up DWI (p = 0.05). Conclusions HARM is a frequent finding in posterior circulation infarction and associated with vessel recanalization, minor infarction growth as well as smaller infarction volumes in the course. Neuroradiologists should be cognizant of the fact that HARM may be present on short interval follow-up FLAIR images in patients with acute ischemic infarction who initially underwent MRI and received intravenous gadolinium-based contrast agents.
DOI:doi:10.1371/journal.pone.0157738
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1371/journal.pone.0157738
 Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157738
 DOI: https://doi.org/10.1371/journal.pone.0157738
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Magnetic resonance imaging
 Blood-brain barrier
 Lesions
 Angiography
 Diffusion weighted imaging
 Infarction
 Ischemic stroke
 Reperfusion
K10plus-PPN:1667517813
Verknüpfungen:→ Zeitschrift

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