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| Verfasst von: | Pretze, Marc [VerfasserIn]  |
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| | Pallavi, Prama [VerfasserIn] |
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| | Klotz, Sarah [VerfasserIn] |
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| | Binzen, Uta [VerfasserIn] |
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| | Greffrath, Wolfgang [VerfasserIn] |
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| | Treede, Rolf-Detlef [VerfasserIn] |
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| | Yard, Benito A. [VerfasserIn] |
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| | Wängler, Carmen [VerfasserIn] |
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| | Wängler, Björn [VerfasserIn] |
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| Titel: | Radiofluorinated N-Octanoyl Dopamine ([18F]F-NOD) as a tool to study tissue distribution and elimination of NOD in vitro and in vivo |
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| Verf.angabe: | Marc Pretze, Prama Pallavi, Mareike Roscher, Sarah Klotz, Julio Caballero, Uta Binzen, Wolfgang Greffrath, Rolf-Detlef Treede, Martin C. Harmsen, Mathias Hafner, Benito Yard, Carmen Wängler, and Björn Wängler |
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| E-Jahr: | 2016 |
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| Jahr: | October 12, 2016 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 18.06.2019 |
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| Titel Quelle: | Enthalten in: Journal of medicinal chemistry |
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| Ort Quelle: | Washington, DC : ACS, 1959 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 59(2016), 21, Seite 9855-9865 |
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| ISSN Quelle: | 1520-4804 |
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| Abstract: | To mitigate pretransplantation injury in organs of potential donors, N-octanoyl dopamine (NOD) treatment might be considered as it does not affect hemodynamic parameters in braindead (BD) donors. To better assess optimal NOD concentrations for donor treatment, we report on the fast and facile radiofluorination of the NOD-derivative [18F]F-NOD [18F]5 for in vivo assessment of NOD’s elimination kinetics by means of PET imaging. [18F]5 was synthesized in reproducibly high radiochemical yields and purity (>98%) as well as high specific activities (>20 GBq/μmol). Stability tests showed no decomposition of [18F]5 over a period of 120 min in rat plasma. In vitro, low cell association was found for [18F]5, indicating no active transport mechanism into cells. In vivo, [18F]5 exhibited a fast blood clearance and a predominant hepatobiliary elimination. As these data suggest that also NOD might be cleared fast, further pharmacokinetic evaluation is warranted. |
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| DOI: | doi:10.1021/acs.jmedchem.6b01191 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1021/acs.jmedchem.6b01191 |
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| | DOI: https://doi.org/10.1021/acs.jmedchem.6b01191 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1667614592 |
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| Verknüpfungen: | → Zeitschrift |
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Radiofluorinated N-Octanoyl Dopamine ([18F]F-NOD) as a tool to study tissue distribution and elimination of NOD in vitro and in vivo / Pretze, Marc [VerfasserIn]; October 12, 2016 (Online-Ressource)
