Nephrotisches Syndrom im Kindesalter

• Verfasst von: Benz, Marcus R. [VerfasserIn]
• Verfasst von: Ehren, Rasmus [VerfasserIn]
• Verfasst von: Tönshoff, Burkhard [VerfasserIn]
• Titel: Nephrotisches Syndrom im Kindesalter
• Verf.angabe: M.R. Benz, R. Ehren, B. Tönshoff, L.T. Weber
• E-Jahr: 2019
• Jahr: 26 March 2019
• Umfang: 12 S.
• Fussnoten: Gesehen am 19.06.2019
• Titel Quelle: Enthalten in: Monatsschrift Kinderheilkunde
• Ort Quelle: Berlin : Springer, 1996
• Jahr Quelle: 2019
• Band/Heft Quelle: 167(2019), 6, Seite 488-499
• ISSN Quelle: 1433-0474
• DOI: doi:10.1007/s00112-019-0677-5
• Datenträger: Online-Ressource
• Sprache: ger
• Sach-SW: Glucocorticoids
• Sach-SW: Glukokortikoide
• Sach-SW: Hypalbuminämie
• Sach-SW: Hypoalbuminemia
• Sach-SW: Immunosuppressive agents
• Sach-SW: Immunsuppressive Agenzien
• Sach-SW: Proteinuria
• Sach-SW: Proteinurie
• Sach-SW: Recurrence
• Sach-SW: Rezidiv
• K10plus-PPN: 166765022X

Abstract

Despite fulfilling the criteria for an orphan disease, idiopathic nephrotic syndrome in children is the most frequent glomerular disease in this age group. Nephrotic syndrome is defined by the detection of a high proteinuria (>1 g/m2 body surface area daily) and hypoalbuminemia (<2,5 g/dl). Edema is also mostly present, especially at the first manifestation. Nephrotic syndrome in children is a heterogeneous disease with respect to age of onset, etiology, histological alterations and response to a standard treatment of glucocorticoids. This diversity strongly influences both the differential diagnostic approach and the treatment. As the prognosis of steroid-sensitive nephrotic syndrome with respect to renal function is generally good, not only the efficacy of an immunosuppressive medication but also the side effect profiles of different immunosuppressive regimens should be kept in mind for treatment planning and optimization.