Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Eichhorn, Tolga [VerfasserIn]  |
| Wendler, Astrid [VerfasserIn]  |
| Krauth-Siegel, Renate [VerfasserIn]  |
Titel: | Bioinformatic and experimental fishing for artemisinin-interacting proteins from human nasopharyngeal cancer cells |
Verf.angabe: | T. Eichhorn, S. Schloissnig, B. Hahn, A. Wendler, Rolf Mertens, W.D. Lehmann, R.L. Krauth-Siegel and T. Efferth |
E-Jahr: | 2012 |
Jahr: | 06 Feb 2012 |
Umfang: | 8 S. |
Fussnoten: | Gesehen am 25.06.2019 |
Titel Quelle: | Enthalten in: Molecular BioSystems |
Ort Quelle: | Cambridge : Royal Society of Chemistry, 2005 |
Jahr Quelle: | 2012 |
Band/Heft Quelle: | 8(2012), 4, Seite 1311-1318 |
ISSN Quelle: | 1742-2051 |
Abstract: | Determining interacting cellular partners of drugs by chemical proteomic techniques is complex and tedious. Most approaches rely on activity-based probe profiling and compound-centric chemical proteomics. The anti-malarial artemisinin also exerts profound anti-cancer activity, but the mechanisms of action are incompletely understood. In the present investigation, we present a novel approach to identify artemisinin-interacting target proteins. Our approach overcomes usual problems in traditional fishing procedures, because the drug was attached to a surface without further chemical modification. The proteins identified effect among others, cell cycle arrest, apoptosis, inhibition of angiogenesis, disruption of cell migration, and modulation of nuclear receptor responsiveness. Furthermore, a bioinformatic approach confirmed experimentally identified proteins and suggested a large number of other interacting proteins. Theoretically predicted interaction partners may serve as a starting point to complete the whole set of proteins binding artemisinin. |
DOI: | doi:10.1039/C2MB05437J |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1039/C2MB05437J |
| Volltext: https://pubs.rsc.org/en/content/articlelanding/2012/mb/c2mb05437j |
| DOI: https://doi.org/10.1039/C2MB05437J |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1667920650 |
Verknüpfungen: | → Zeitschrift |
Bioinformatic and experimental fishing for artemisinin-interacting proteins from human nasopharyngeal cancer cells / Eichhorn, Tolga [VerfasserIn]; 06 Feb 2012 (Online-Ressource)
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