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Verfasst von:Saeedi, Mohammed al [VerfasserIn]   i
 Schultze, Daniel [VerfasserIn]   i
 Nickkholgh, Arash [VerfasserIn]   i
 Herr, Ingrid [VerfasserIn]   i
 Zorn, Markus [VerfasserIn]   i
Titel:Glycine protects partial liver grafts from Kupffer cell-dependent ischemia-reperfusion injury without negative effect on regeneration
Verf.angabe:Mohammed Al-Saeedi, Rui Liang, Daniel P. Schultze, Arash Nickkholgh, Ingrid Herr, Markus Zorn, Peter Schemmer
E-Jahr:2019
Jahr:02 April 2019
Umfang:9 S.
Fussnoten:Gesehen am 27.06.2019
Titel Quelle:Enthalten in: Amino acids
Ort Quelle:Wien [u.a.] : Springer, 1991
Jahr Quelle:2019
Band/Heft Quelle:51(2019), 6, Seite 903-911
ISSN Quelle:1438-2199
Abstract:Donor preconditioning with glycine prevents Kupffer cell-dependent reperfusion injury to liver grafts. Partial liver grafts need to regenerate and grow in size after transplantation; however, glycine inactivates Kupffer cells, which are important for hepatic regeneration. Thus, this study was designed to evaluate the impact of donor preconditioning with glycine after partial liver transplantation (pLTx). PLTx was performed in 28 female Sprague-Dawley rats. Glycine (1.5 ml, 300 mM; i.v.) was given to 14 live donors before organ procurement. Liver enzymes and histology were investigated 8 h after reperfusion to index liver injury and leukocyte infiltration. Hepatic microperfusion and leukocyte-endothelium interaction were assessed using the in vivo fluorescence microscopy method. Ki-67 and TNF-α were detected by immunohistochemistry for regeneration and Kupffer cell activation. Glycine significantly increased survival from 0% in controls to 40%, while both liver enzyme levels and necrosis were decreased to about 50% of controls (p < 0.05). Sinusoidal blood flow increased by 40-80%, while leukocyte-endothelium interaction decreased to 30% of control values (p < 0.05). While Kupffer cell-derived TNF-α decreased to 70% of controls, there was no difference between groups in Ki-67 expression. Data presented here clearly demonstrate that glycine protects partial liver grafts from reperfusion injury without effects on regeneration.
DOI:doi:10.1007/s00726-019-02722-5
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1007/s00726-019-02722-5
 DOI: https://doi.org/10.1007/s00726-019-02722-5
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Glycine
 Ischemia-/reperfusion injury
 Ki-67
 Kupffer cells
 Partial liver transplantation
 Regeneration
 TNF-α
K10plus-PPN:166802392X
Verknüpfungen:→ Zeitschrift

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