| Online-Ressource |
Verfasst von: | Correia, Margareta [VerfasserIn]  |
| Stojanovic, Ana [VerfasserIn]  |
| Bauer, Katharina [VerfasserIn]  |
| Juraeva, Dilafruz [VerfasserIn]  |
| Tykocinski, Lars-Oliver [VerfasserIn]  |
| Lorenz, Hanns-Martin [VerfasserIn]  |
| Brors, Benedikt [VerfasserIn]  |
| Cerwenka, Adelheid [VerfasserIn]  |
Titel: | Distinct human circulating NKp30+FcεRIγ+CD8+ T cell population exhibiting high natural killer-like antitumor potential |
Verf.angabe: | Margareta P. Correia, Ana Stojanovic, Katharina Bauer, Dilafruz Juraeva, Lars-Oliver Tykocinski, Hanns-Martin Lorenz, Benedikt Brors, Adelheid Cerwenka |
E-Jahr: | 2018 |
Jahr: | [June 26, 2018] |
Umfang: | 10 S. |
Fussnoten: | Published online June 12, 2018 ; Gesehen am 28.06.2019 |
Titel Quelle: | Enthalten in: National Academy of Sciences (Washington, DC)Proceedings of the National Academy of Sciences of the United States of America |
Ort Quelle: | Washington, DC : National Acad. of Sciences, 1915 |
Jahr Quelle: | 2018 |
Band/Heft Quelle: | 115 (2018,26), Seite E5980-E5989, 10 Seiten |
ISSN Quelle: | 1091-6490 |
Abstract: | CD8+ T cells are considered prototypical cells of adaptive immunity. Here, we uncovered a distinct CD8+ T cell population expressing the activating natural killer (NK) receptor NKp30 in the peripheral blood of healthy individuals. We revealed that IL-15 could de novo induce NKp30 expression in a population of CD8+ T cells and drive their differentiation toward a broad innate transcriptional landscape. The adaptor FcεRIγ was concomitantly induced and was shown to be crucial to enable NKp30 cell-surface expression and function in CD8+ T cells. FcεRIγ de novo expression required promoter demethylation and was accompanied by acquisition of the signaling molecule Syk and the “innate” transcription factor PLZF. IL-15-induced NKp30+CD8+ T cells exhibited high NK-like antitumor activity in vitro and were able to synergize with T cell receptor signaling. Importantly, this population potently controlled tumor growth in a preclinical xenograft mouse model. Our study, while blurring the borders between innate and adaptive immunity, reveals a unique NKp30+FcεRIγ+CD8+ T cell population with high antitumor therapeutic potential. |
DOI: | doi:10.1073/pnas.1720564115 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1073/pnas.1720564115 |
| Volltext: https://www.pnas.org/content/115/26/E5980 |
| DOI: https://doi.org/10.1073/pnas.1720564115 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | anti-tumor |
| CD8+ T cells |
| IL-15 |
| innate |
| NKp30 |
K10plus-PPN: | 1668116359 |
Verknüpfungen: | → Zeitschrift |
Distinct human circulating NKp30+FcεRIγ+CD8+ T cell population exhibiting high natural killer-like antitumor potential / Correia, Margareta [VerfasserIn]; [June 26, 2018] (Online-Ressource)