Plasma parathyroid hormone is independently related to nocturnal blood pressure in hypertensive patients

• Verfasst von: Verheyen, Nicolas [VerfasserIn]
• Verfasst von: März, Winfried [VerfasserIn]
• Titel: Plasma parathyroid hormone is independently related to nocturnal blood pressure in hypertensive patients
• Titelzusatz: the Styrian Hypertension Study
• Verf.angabe: Nicolas D. Verheyen MD; Katharina Kienreich MD; Martin Gaksch MD; Adriana J. van Ballegooijen PhD; Martin R. Grübler MD; Briain Ó. Hartaigh PhD; Johannes Schmid MD; Astrid Fahrleitner‐Pammer MD; Elisabeth Kraigher‐Krainer MD; Caterina Colantonio MD; Evgeny Belyavskiy MD; Gerlies Treiber MD, PhD; Cristiana Catena MD; Helmut Brussee MD, PhD; Burkert Pieske MD, PhD; Winfried März MD, PhD; Andreas Tomaschitz MD; Stefan Pilz MD, PhD
• Jahr: 2016
• Jahr des Originals: 2015
• Umfang: 8 S.
• Fussnoten: Gesehen am 01.07.2019 ; First published: 12 October 2015
• Titel Quelle: Enthalten in: The journal of clinical hypertension
• Ort Quelle: Hoboken, NJ : Wiley, 2001
• Jahr Quelle: 2016
• Band/Heft Quelle: 18(2016), 6, Seite 543-550
• ISSN Quelle: 1751-7176
• DOI: doi:10.1111/jch.12710
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1668140292

Abstract

High parathyroid hormone (PTH) has been linked with high blood pressure (BP), but the relationship with 24-hour ambulatory blood pressure monitoring is largely unknown. The authors therefore analyzed cross-sectional data of 292 hypertensive patients participating in the Styrian Hypertension Study (mean age, 61±11 years; 53% women). Median plasma PTH (interquartile range) determined after an overnight fast was 49 pg/mL (39-61), mean daytime BP was 131/80±12/9 mm Hg, and mean nocturnal BP was 115/67±14/9 mm Hg. In multivariate regression analyses adjusted for BP and PTH-modifying parameters, PTH was significantly related to nocturnal systolic and diastolic BP (adjusted β-coefficient 0.140 [P=.03] and 0.175 [P<.01], respectively). PTH was not correlated with daytime BP readings. These data suggest a direct interrelationship between PTH and nocturnal BP regulation. Whether lowering high PTH concentrations reduces the burden of high nocturnal BP remains to be shown in future studies.