Impaired and preserved aspects of feedback learning in aMCI

• Verfasst von: Wessa, Michèle [VerfasserIn]
• Verfasst von: Frölich, Lutz [VerfasserIn]
• Verfasst von: Flor, Herta [VerfasserIn]
• Titel: Impaired and preserved aspects of feedback learning in aMCI
• Titelzusatz: contributions of structural connectivity
• Verf.angabe: Michèle Wessa, Andrea V. King, Patric Meyer, Lutz Frölich, Herta Flor, Cyril Poupon, Michael Hoppstädter, Julia Linke
• Jahr: 2016
• Jahr des Originals: 2015
• Umfang: 16 S.
• Fussnoten: Gesehen am 01.07.2019 ; Published online: 18 June 2015
• Titel Quelle: Enthalten in: Brain structure & function
• Ort Quelle: Berlin : Springer, 2007
• Jahr Quelle: 2016
• Band/Heft Quelle: 221(2016), 5, Seite 2831-2846
• ISSN Quelle: 1863-2661
• DOI: doi:10.1007/s00429-015-1075-y
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Amnestic mild cognitive impairment
• Sach-SW: Amygdala
• Sach-SW: Diffusion tensor imaging
• Sach-SW: Entorhinal cortex
• Sach-SW: Hippocampus
• Sach-SW: Tractography
• K10plus-PPN: 1668174693

Abstract

Distinct lines of research demonstrated that patients with amnestic mild cognitive impairment (aMCI), a potential precursor of Alzheimer disease (AD), are particularly impaired in remembering relations between items and that the use of emotional targets can facilitate memory in patients with AD. We link these findings by examining learning through positive and negative feedback in patients with aMCI, and explore its anatomic underpinnings with diffusion tensor imaging and tractography. Compared to healthy controls, patients with single-domain aMCI were impaired in learning from positive feedback, while learning from negative outcomes was preserved. Among pathways within the brain circuit involved in feedback learning, abnormal white matter microstructure was observed in tracts, which connect left-hemispheric amygdala with hippocampus and entorhinal cortex. In all participants, reduced white matter integrity in this left fiber tract was specifically associated with learning from positive outcomes. Microstructure of right-hemispheric tracts between amygdala and entorhinal cortex was related to learning from negative feedback, and was not compromised in aMCI patients. Our results provide new insight into how anatomical connections might contribute to impaired and preserved aspects of learning behaviors in the early AD process and indicate potential compensatory mechanisms.