Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Bumb, Jan Malte [VerfasserIn]   i
 Nölte, Ingo [VerfasserIn]   i
 Schredl, Michael [VerfasserIn]   i
 Kirsch, Peter [VerfasserIn]   i
 Leweke, F. Markus [VerfasserIn]   i
 Sobanski, Esther [VerfasserIn]   i
Titel:Associations of pineal volume, chronotype and symptom severity in adults with attention deficit hyperactivity disorder and healthy controls
Verf.angabe:Jan Malte Bumb, Daniela Mier, Ingo Noelte, Michael Schredl, Peter Kirsch, Oliver Hennig, Luisa Liebrich, Sabrina Fenske, Barbara Alm, Carina Sauer, Franz Markus Leweke, Esther Sobanski
E-Jahr:2016
Jahr:July 2016
Umfang:8 S.
Fussnoten:Gesehen am 05.07.2019
Titel Quelle:Enthalten in: European neuropsychopharmacology
Ort Quelle:Amsterdam : Elsevier, 1990
Jahr Quelle:2016
Band/Heft Quelle:26(2016), 7, Seite 1119-1126
ISSN Quelle:1873-7862
Abstract:The pineal gland, as part of the human epithalamus, is the main production site of peripheral melatonin, which promotes the modulation of sleep patterns, circadian rhythms and circadian preferences (morningness vs. eveningness). The present study analyses the pineal gland volume (PGV) and its association with circadian preferences and symptom severity in adult ADHD patients compared to healthy controls. PGV was determined manually using high-resolution 3T MRI (T1-magnetization prepared rapid gradient echo) in medication free adult ADHD patients (N=74) compared to healthy controls (N=86). Moreover, the Morningness-Eveningness Questionnaire (MEQ), the ADHD Diagnostic Checklist and the Wender-Utah Rating Scale were conducted. PGV differed between both groups (patients: 59.9±33.8mm3; healthy controls: 71.4±27.2mm3, P=0.04). In ADHD patients, more eveningness types were revealed (patients: 29%; healthy controls: 17%; P=0.05) and sum scores of the MEQ were lower (patients: 45.8±11.5; healthy controls 67.2±10.1; P<0.001). Multiple regression analyses indicated a positive correlation of PGV and MEQ scores in ADHD (β=0.856, P=0.003) but not in healthy controls (β=0.054, P=0.688). Patients’ MEQ scores (β=−0.473, P=0.003) were negatively correlated to ADHD symptoms. The present results suggest a linkage between the PGV and circadian preference in adults with ADHD and an association of the circadian preference to symptom severity. This may facilitate the development of new chronobiological treatment approaches for the add-on treatment in ADHD.
DOI:doi:10.1016/j.euroneuro.2016.03.016
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.euroneuro.2016.03.016
 Volltext: http://www.sciencedirect.com/science/article/pii/S0924977X16300141
 DOI: https://doi.org/10.1016/j.euroneuro.2016.03.016
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Eveningness
 Melatonin
 MEQ
 Morningness
 MPRAGE
 MRI
K10plus-PPN:1668675021
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68405324   QR-Code
zum Seitenanfang