Heterogeneity of acute multiple sclerosis lesions on sodium (23Na) MRI

• Verfasst von: Eisele, Philipp [VerfasserIn]
• Verfasst von: Griebe, Martin [VerfasserIn]
• Verfasst von: Szabo, Kristina [VerfasserIn]
• Verfasst von: Wolf, Marc [VerfasserIn]
• Verfasst von: Alonso, Angelika [VerfasserIn]
• Verfasst von: Ebert, Anne [VerfasserIn]
• Verfasst von: Roßmanith, Christina [VerfasserIn]
• Verfasst von: Hennerici, Michael G. [VerfasserIn]
• Verfasst von: Schad, Lothar R. [VerfasserIn]
• Verfasst von: Gass, Achim [VerfasserIn]
• Titel: Heterogeneity of acute multiple sclerosis lesions on sodium (23Na) MRI
• Verf.angabe: Philipp Eisele, Simon Konstandin, Martin Griebe, Kristina Szabo, Marc E Wolf, Angelika Alonso, Anne Ebert, Julia Serwane, Christina Rossmanith, Michael G Hennerici, Lothar R Schad and Achim Gass
• Jahr: 2016
• Umfang: 8 S.
• Fussnoten: Gesehen am 05.07.2019 ; First Published October 9, 2015 ; Im Titel ist die Zahl "23" hochgestellt
• Titel Quelle: Enthalten in: Multiple sclerosis journal
• Ort Quelle: London : Sage, 1995
• Jahr Quelle: 2016
• Band/Heft Quelle: 22(2016), 8, Seite 1040-1047
• ISSN Quelle: 1477-0970
• DOI: doi:10.1177/1352458515609430
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1668699540

Abstract

Background: Advanced magnetic resonance imaging (MRI) techniques provide a window into pathological processes in multiple sclerosis (MS). Nevertheless, to date only few studies have performed sodium MRI in MS. Objectives: We analysed total sodium concentration (TSC) in hyperacute, acute and chronic lesions in MS with 23Na MRI. Methods: 23Na MRI and 1H MRI were performed in 65 MS patients and 10 healthy controls (HC). Mean TSC was quantified in all MS lesions with a diameter of >5 mm and in the normal appearing white and grey matter (NAWM, NAGM). Results: TSC in the NAWM and the NAGM of MS patients was significantly higher compared to HC (WM: 37.51 ± 2.65 mM versus 35.17 ± 3.40 mM; GM: 43.64 ± 2.75 mM versus 40.09 ± 4.64 mM). Acute and chronic MS lesions showed elevated TSC levels of different extent (contrast-enhancing lesions (49.07 ± 6.99 mM), T1 hypointense lesions (45.06 ± 6.26 mM) and remaining T1 isointense lesions (39.88 ± 5.54 mM)). However, non-enhancing hyperacute lesions with a reduced apparent diffusion coefficient showed a TSC comparable to the NAWM (37.22 ± 4.62 mM). Conclusions: TSC is not only a sensitive marker of the severity of chronic tissue abnormalities in MS but is also highly sensitive to opening of the blood-brain barrier and vasogenic tissue oedema in contrast-enhancing lesions.