| Online-Ressource |
Verfasst von: | Eisele, Philipp [VerfasserIn]  |
| Griebe, Martin [VerfasserIn]  |
| Szabo, Kristina [VerfasserIn]  |
| Wolf, Marc [VerfasserIn]  |
| Alonso, Angelika [VerfasserIn]  |
| Ebert, Anne [VerfasserIn]  |
| Roßmanith, Christina [VerfasserIn]  |
| Hennerici, Michael G. [VerfasserIn]  |
| Schad, Lothar R. [VerfasserIn]  |
| Gass, Achim [VerfasserIn]  |
Titel: | Heterogeneity of acute multiple sclerosis lesions on sodium (23Na) MRI |
Verf.angabe: | Philipp Eisele, Simon Konstandin, Martin Griebe, Kristina Szabo, Marc E Wolf, Angelika Alonso, Anne Ebert, Julia Serwane, Christina Rossmanith, Michael G Hennerici, Lothar R Schad and Achim Gass |
Jahr: | 2016 |
Umfang: | 8 S. |
Fussnoten: | Gesehen am 05.07.2019 ; First Published October 9, 2015 ; Im Titel ist die Zahl "23" hochgestellt |
Titel Quelle: | Enthalten in: Multiple sclerosis journal |
Ort Quelle: | London : Sage, 1995 |
Jahr Quelle: | 2016 |
Band/Heft Quelle: | 22(2016), 8, Seite 1040-1047 |
ISSN Quelle: | 1477-0970 |
Abstract: | Background: Advanced magnetic resonance imaging (MRI) techniques provide a window into pathological processes in multiple sclerosis (MS). Nevertheless, to date only few studies have performed sodium MRI in MS. Objectives: We analysed total sodium concentration (TSC) in hyperacute, acute and chronic lesions in MS with 23Na MRI. Methods: 23Na MRI and 1H MRI were performed in 65 MS patients and 10 healthy controls (HC). Mean TSC was quantified in all MS lesions with a diameter of >5 mm and in the normal appearing white and grey matter (NAWM, NAGM). Results: TSC in the NAWM and the NAGM of MS patients was significantly higher compared to HC (WM: 37.51 ± 2.65 mM versus 35.17 ± 3.40 mM; GM: 43.64 ± 2.75 mM versus 40.09 ± 4.64 mM). Acute and chronic MS lesions showed elevated TSC levels of different extent (contrast-enhancing lesions (49.07 ± 6.99 mM), T1 hypointense lesions (45.06 ± 6.26 mM) and remaining T1 isointense lesions (39.88 ± 5.54 mM)). However, non-enhancing hyperacute lesions with a reduced apparent diffusion coefficient showed a TSC comparable to the NAWM (37.22 ± 4.62 mM). Conclusions: TSC is not only a sensitive marker of the severity of chronic tissue abnormalities in MS but is also highly sensitive to opening of the blood-brain barrier and vasogenic tissue oedema in contrast-enhancing lesions. |
DOI: | doi:10.1177/1352458515609430 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1177/1352458515609430 |
| DOI: https://doi.org/10.1177/1352458515609430 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1668699540 |
Verknüpfungen: | → Zeitschrift |
Heterogeneity of acute multiple sclerosis lesions on sodium (23Na) MRI / Eisele, Philipp [VerfasserIn]; 2016 (Online-Ressource)