Status: Bibliographieeintrag
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| Verfasst von: | Ruiter, Marvin [VerfasserIn]  |
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| | Malsam, Andrea [VerfasserIn] |
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| | Malsam, Jörg [VerfasserIn] |
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| | Söllner, Thomas [VerfasserIn] |
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| Titel: | An electrostatic energy barrier for SNARE-dependent spontaneous and evoked synaptic transmission |
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| Verf.angabe: | Marvin Ruiter, Anna Kádková, Andrea Scheutzow, Jörg Malsam, Thomas H. Söllner, Jakob B. Sørensen |
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| E-Jahr: | 2019 |
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| Jahr: | 26 February 2019 |
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| Umfang: | 19 S. |
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| Fussnoten: | Gesehen am 08.07.2019 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 26(2019,9), Seite 2340-2352.e5, 19 Seiten |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | Summary - Information transfer across CNS synapses depends on the very low basal vesicle fusion rate and the ability to rapidly upregulate that rate upon Ca2+ influx. We show that local electrostatic repulsion participates in creating an energy barrier, which limits spontaneous synaptic transmission. The barrier amplitude is increased by negative charges and decreased by positive charges on the SNARE-complex surface. Strikingly, the effect of charges on the barrier is additive and this extends to evoked transmission, but with a shallower charge dependence. Action potential-driven synaptic release is equivalent to the abrupt addition of ∼35 positive charges to the fusion machine. Within an electrostatic model for triggering, the Ca2+ sensor synaptotagmin-1 contributes ∼18 charges by binding Ca2+, while also modulating the fusion barrier at rest. Thus, the energy barrier for synaptic vesicle fusion has a large electrostatic component, allowing synaptotagmin-1 to act as an electrostatic switch and modulator to trigger vesicle fusion. |
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| DOI: | doi:10.1016/j.celrep.2019.01.103 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.celrep.2019.01.103 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S2211124719301408 |
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| | DOI: https://doi.org/10.1016/j.celrep.2019.01.103 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | autaptic neuron |
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| | energy barrier |
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| | glutamatergic synapse |
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| | mathematical modeling |
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| | membrane fusion |
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| | SNAP-25 |
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| | SNARE-complex |
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| | spontaneous release |
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| | synaptic transmission |
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| | synaptotagmin-1 |
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| K10plus-PPN: | 1668733269 |
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| Verknüpfungen: | → Zeitschrift |
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¬An¬ electrostatic energy barrier for SNARE-dependent spontaneous and evoked synaptic transmission / Ruiter, Marvin [VerfasserIn]; 26 February 2019 (Online-Ressource)
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