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Status: Bibliographieeintrag

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Verfasst von:Gass, Natalia [VerfasserIn]   i
 Sartorius, Alexander [VerfasserIn]   i
 Meyer-Lindenberg, Andreas [VerfasserIn]   i
Titel:An acetylcholine alpha7 positive allosteric modulator rescues a schizophrenia-associated brain endophenotype in the 15q13.3 microdeletion, encompassing CHRNA7
Verf.angabe:Natalia Gass, Wolfgang Weber-Fahr, Alexander Sartorius, Robert Becker, Michael Didriksen, Tine Bryan Stensbøl, Jesper Frank Bastlund, Andreas Meyer-Lindenberg, Adam J. Schwarz
E-Jahr:2016
Jahr:July 2016
Umfang:11 S.
Fussnoten:Gesehen am 08.07.2019
Titel Quelle:Enthalten in: European neuropsychopharmacology
Ort Quelle:Amsterdam : Elsevier, 1990
Jahr Quelle:2016
Band/Heft Quelle:26(2016), 7, Seite 1150-1160
ISSN Quelle:1873-7862
Abstract:The 15q13.3 microdeletion copy number variation is strongly associated with schizophrenia and epilepsy. The CHRNA7 gene, encoding nicotinic acetylcholine alpha 7 receptors (nAChA7Rs), is hypothesized to be one of the main genes in this deletion causing the neuropsychiatric phenotype. Here we used a recently developed 15q13.3 microdeletion mouse model to explore whether an established schizophrenia-associated connectivity phenotype is replicated in a murine model, and whether positive modulation of nAChA7 receptor might pharmacologically normalize the connectivity patterns. Resting-state fMRI data were acquired from male mice carrying a hemizygous 15q13.3 microdeletion (N=9) and from wild-type mice (N=9). To study the connectivity profile of 15q13.3 mice and test the effect of nAChA7 positive allosteric modulation, the 15q13.3 mice underwent two imaging sessions, one week apart, receiving a single intraperitoneal injection of either 15mg/kg Lu AF58801 or saline. The control group comprised wild-type mice treated with saline. We performed seed-based functional connectivity analysis to delineate aberrant connectivity patterns associated with the deletion (15q13.3 mice (saline treatment) versus wild-type mice (saline treatment)) and their modulation by Lu AF58801 (15q13.3 mice (Lu AF58801 treatment) versus 15q13.3 mice (saline treatment)). Compared to wild-type mice, 15q13.3 mice evidenced a predominant hyperconnectivity pattern. The main effect of Lu AF58801 was a normalization of elevated functional connectivity between prefrontal and frontal, hippocampal, striatal, thalamic and auditory regions. The strongest effects were observed in brain regions expressing nAChA7Rs, namely hippocampus, cerebral cortex and thalamus. These effects may underlie the antiepileptic, pro-cognitive and auditory gating deficit-reversal effects of nAChA7R stimulation.
DOI:doi:10.1016/j.euroneuro.2016.03.013
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.euroneuro.2016.03.013
 Volltext: http://www.sciencedirect.com/science/article/pii/S0924977X16300116
 DOI: https://doi.org/10.1016/j.euroneuro.2016.03.013
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:15q13.3 Microdeletion
 Mouse model
 Resting-state fMRI
 Schizophrenia
K10plus-PPN:1668733927
Verknüpfungen:→ Zeitschrift

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