Perfusion-weighted imaging and dynamic 4D angiograms for the estimation of collateral blood flow in lacunar infarction

• Verfasst von: Förster, Alex [VerfasserIn]
• Verfasst von: Mürle, Bettina [VerfasserIn]
• Verfasst von: Böhme, Johannes [VerfasserIn]
• Verfasst von: Al-Zghloul, Mansour [VerfasserIn]
• Verfasst von: Kerl, Hans Ulrich [VerfasserIn]
• Verfasst von: Wenz, Holger [VerfasserIn]
• Verfasst von: Groden, Christoph [VerfasserIn]
• Titel: Perfusion-weighted imaging and dynamic 4D angiograms for the estimation of collateral blood flow in lacunar infarction
• Verf.angabe: Alex Förster, Bettina Mürle, Johannes Böhme, Mansour Al-Zghloul, Hans U Kerl, Holger Wenz and Christoph Groden
• Jahr: 2016
• Umfang: 11 S.
• Fussnoten: Gesehen am 08.07.2019 ; First Published October 14, 2015
• Titel Quelle: Enthalten in: Journal of cerebral blood flow & metabolism
• Ort Quelle: Thousands Oaks, Calif. : Sage, 1981
• Jahr Quelle: 2016
• Band/Heft Quelle: 36(2016), 10, Seite 1744-1754
• ISSN Quelle: 1559-7016
• DOI: doi:10.1177/0271678X15606458
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1668738511

Abstract

Although lacunar infarction accounts for approximately 25% of ischemic strokes, collateral blood flow through anastomoses is not well evaluated in lacunar infarction. In 111 lacunar infarction patients, we analyzed diffusion-weighted images, perfusion-weighted images, and blood flow on dynamic four-dimensional angiograms generated by use of Signal Processing In NMR-Software. Blood flow was classified as absent (type 1), from periphery to center (type 2), from center to periphery (type 3), and combination of type 2 and 3 (type 4). On diffusion-weighted images, lacunar infarction was found in the basal ganglia (11.7%), internal capsule (24.3%), corona radiata (30.6%), thalamus (24.3%), and brainstem (9.0%). In 58 (52.2%) patients, perfusion-weighted image showed a circumscribed hypoperfusion, in one (0.9%) a circumscribed hyperperfusion, whereas the remainder was normal. In 36 (62.1%) patients, a larger perfusion deficit (>7 mm) was observed. In these, blood flow was classified type 1 in four (11.1%), 2 in 17 (47.2%), 3 in 9 (25.0%), and 4 in six (16.7%) patients. Patients with lacunar infarction in the posterior circulation more often demonstrated blood flow type 2 and less often type 3 (p = 0.01). Detailed examination and graduation of blood flow in lacunar infarction by use of dynamic four-dimensional angiograms is feasible and may serve for a better characterization of this stroke subtype.