| |  Online-Ressource |
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| Verfasst von: | Dvornikov, Dmytro [VerfasserIn]  |
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| | Schneider, Marc [VerfasserIn] |
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| | Szczygieł, Magdalena [VerfasserIn] |
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| | Titkova, Irina [VerfasserIn] |
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| | Muley, Thomas [VerfasserIn] |
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| | Warth, Arne [VerfasserIn] |
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| | Herth, Felix [VerfasserIn] |
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| | Dienemann, Hendrik [VerfasserIn] |
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| | Thomas, Michael [VerfasserIn] |
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| | Meister, Michael [VerfasserIn] |
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| Titel: | Expression ratio of the TGFβ-inducible gene MYO10 is prognostic for overall survival of squamous cell lung cancer patients and predicts chemotherapy response |
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| Verf.angabe: | D. Dvornikov, M.A. Schneider, S. Ohse, M. Szczygieł, I. Titkova, M. Rosenblatt, T. Muley, A. Warth, F.J. Herth, H. Dienemann, M. Thomas, J. Timmer, M. Schilling, H. Busch, M. Boerries, M. Meister & U. Klingmüller |
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| E-Jahr: | 2018 |
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| Jahr: | 22 June 2018 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 09.07.2019 |
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| Titel Quelle: | Enthalten in: Scientific reports |
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| Ort Quelle: | [London] : Macmillan Publishers Limited, part of Springer Nature, 2011 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 8(2018) Artikel-Nummer 9517, 13 Seiten |
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| ISSN Quelle: | 2045-2322 |
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| Abstract: | In lung cancer a deregulation of Transforming Growth Factor-β (TGFβ) signaling has been observed. Yet, the impact of TGFβ in squamous cell carcinoma of the lung (LUSC) remained to be determined. We combined phenotypic and transcriptome-wide studies and showed that the stimulation of the LUSC cell line SK-MES1 with TGFβ results in an increase of migratory invasive properties. The analysis of the dynamics of gene expression by next-generation sequencing revealed that TGFβ stimulation orchestrates the upregulation of numerous motility- and actin cytoskeleton-related genes. Among these the non-muscle myosin 10 (MYO10) showed the highest upregulation in a LUSC patient cohort of the Cancer Genome Atlas (TCGA). Knockdown of MYO10 abrogated TGFβ-induced collagen gel invasion of SK-MES1 cells. The analysis of MYO10 mRNA expression in paired tissues of 151 LUSC patients with corresponding 80-month clinical follow-up data showed that the mRNA expression ratio of MYO10 in tumor and tumor-free tissue is prognostic for overall survival of LUSC patients and predictive for the response of these patients to adjuvant chemotherapy. Thus, MYO10 represents a new clinical biomarker for this aggressive disease and due to its role in cellular motility and invasion could serve as a potential molecular target for therapeutic interventions in patients with LUSC. |
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| DOI: | doi:10.1038/s41598-018-27912-1 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/s41598-018-27912-1 |
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| | Volltext: https://www.nature.com/articles/s41598-018-27912-1 |
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| | DOI: https://doi.org/10.1038/s41598-018-27912-1 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1668805251 |
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| Verknüpfungen: | → Zeitschrift |
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Expression ratio of the TGFβ-inducible gene MYO10 is prognostic for overall survival of squamous cell lung cancer patients and predicts chemotherapy response / Dvornikov, Dmytro [VerfasserIn]; 22 June 2018 (Online-Ressource)
