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Verfasst von:Rohleder, Cathrin [VerfasserIn]   i
 Leweke, F. Markus [VerfasserIn]   i
Titel:The functional networks of prepulse inhibition
Titelzusatz:neuronal connectivity analysis based on FDG-PET in awake and unrestrained rats
Verf.angabe:Cathrin Rohleder, Dirk Wiedermann, Bernd Neumaier, Alexander Drzezga, Lars Timmermann, Rudolf Graf, F. Markus Leweke and Heike Endepols
E-Jahr:2016
Jahr:21 July 2016
Umfang:10 S.
Fussnoten:Gesehen am 09.07.2019
Titel Quelle:Enthalten in: Frontiers in behavioral neuroscience
Ort Quelle:Lausanne : Frontiers Research Foundation, 2007
Jahr Quelle:2016
Band/Heft Quelle:10(2016) Artikel-Nummer 148, 10 Seiten
ISSN Quelle:1662-5153
Abstract:Prepulse inhibition (PPI) is a neuropsychological process during which a weak sensory stimulus (“prepulse”) attenuates the motor response (“startle reaction”) to a subsequent strong startling stimulus. It is measured as a surrogate marker of sensorimotor gating in patients suffering from neuropsychological diseases such as schizophrenia, as well as in corresponding animal models. A variety of studies has shown that PPI of the acoustical startle reaction comprises three brain circuitries for: i) startle mediation, ii) PPI mediation and iii) modulation of PPI mediation. While anatomical connections and information flow in the startle and PPI mediation pathways are well known, spatial and temporal interactions of the numerous regions involved in PPI modulation are incompletely understood. We therefore combined [18F]fluoro-2-deoxyglucose positron-emission-tomography (FDG-PET) with PPI and resting state control paradigms in awake rats. A battery of subtractive, correlative as well as seed-based functional connectivity analyses revealed a default mode-like network (DMN) active during resting state only. Furthermore, two functional networks were observed during PPI: Metabolic activity in the lateral circuitry was positively correlated with PPI effectiveness and involved the auditory system and emotional regions. The medial network was negatively correlated with PPI effectiveness, i.e. associated with startle, and recruited a spatial/cognitive network. Our study provides evidence for two distinct neuronal networks, whose continuous interplay determines PPI effectiveness in rats, probably by either protecting the prepulse or facilitating startle processing. Discovering similar networks affected in neuropsychological disorders may help to better understand mechanisms of sensorimotor gating deficits and provide new perspectives for therapeutic strategies.
DOI:doi:10.3389/fnbeh.2016.00148
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.3389/fnbeh.2016.00148
 Volltext: https://www.frontiersin.org/articles/10.3389/fnbeh.2016.00148/full
 DOI: https://doi.org/10.3389/fnbeh.2016.00148
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Behavioral PET
 cerebral glucose consumption
 Metabolic connectivity
 PPI modulation
 PPI Network
K10plus-PPN:1668815389
Verknüpfungen:→ Zeitschrift

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