| Online-Ressource |
Verfasst von: | Heller, Raban [VerfasserIn]  |
| Seelig, Julian [VerfasserIn]  |
| Bock, Tobias [VerfasserIn]  |
| Haubruck, Patrick [VerfasserIn]  |
| Grützner, Paul Alfred [VerfasserIn]  |
| Schomburg, Lutz [VerfasserIn]  |
| Moghaddam-Alvandi, Arash [VerfasserIn]  |
| Biglari, Bahram [VerfasserIn]  |
Titel: | Relation of selenium status to neuro-regeneration after traumatic spinal cord injury |
Verf.angabe: | Raban Arved Heller, Julian Seelig, Tobias Bock, Patrick Haubruck, Paul Alfred Grützner, Lutz Schomburg, Arash Moghaddam, Bahram Biglari |
Jahr: | 2019 |
Jahr des Originals: | 2018 |
Umfang: | 9 S. |
Fussnoten: | Available online 12 October 2018 ; Gesehen am 09.07.2019 |
Titel Quelle: | Enthalten in: Journal of trace elements in medicine and biology |
Ort Quelle: | München : Elsevier, 1995 |
Jahr Quelle: | 2019 |
Band/Heft Quelle: | 51(2019), Seite 141-149 |
ISSN Quelle: | 1878-3252 |
Abstract: | Introduction - The trace element selenium (Se) is crucial for the biosynthesis of selenoproteins. Both neurodevelopment and the survival of neurons that are subject to stress depend on a regular selenoprotein biosynthesis and sufficient Se supply by selenoprotein P (SELENOP). - Hypothesis - Neuro-regeneration after traumatic spinal cord injury (TSCI) is related to the Se status. - Study design - Single-centre prospective observational study. - Patients and methods - Three groups of patients with comparable injuries were studied; vertebral fractures without neurological impairment (n = 10, group C), patients with TSCI showing no remission (n = 9, group G0), and patients with remission developing positive abbreviated injury score (AIS) conversion within 3 months (n = 10, group G1). Serum samples were available from different time points (upon admission, and after 4, 9 and 12 h, 1 and 3 days, 1 and 2 weeks, and 1, 2 and 3 months). Serum trace element concentrations were determined by total reflection X-ray fluorescence, SELENOP by ELISA, and further parameters by laboratory routine. - Results - Serum Se and SELENOP concentrations were higher on admission in the remission group (G1) as compared to G0. During the first week, both parameters remained constant in C and G0, whereas they declined significantly in the remission group. Similarly, the concentration changes between admission and 24 h were most pronounced in this group of recovering patients (G1). Binary logistic regression analysis including the delta of Se and SELENOP within the first 24 h indicated an AUC of 90.0% (CI: 67.4%-100.0%) with regards to predicting the outcome after TSCI. - Conclusion - A Se deficit might constitute a risk factor for poor outcome after TSCI. A dynamic decline of serum Se and SELENOP concentrations after admission may reflect ongoing repair processes that are associated with higher odds for a positive clinical outcome. |
DOI: | doi:10.1016/j.jtemb.2018.10.006 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.jtemb.2018.10.006 |
| Volltext: http://www.sciencedirect.com/science/article/pii/S0946672X18304577 |
| DOI: https://doi.org/10.1016/j.jtemb.2018.10.006 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Biomarker |
| Brain |
| ELISA |
| Inflammation |
| Injury |
| Neurodegeneration |
| Neuron |
| Paraplegia |
| Precision medicine |
| Prediction |
| Profile |
| Recovery |
| Selenoprotein P |
| Supplementation |
| Surgery |
| Trace element |
| Zinc |
K10plus-PPN: | 1668834472 |
Verknüpfungen: | → Zeitschrift |
Relation of selenium status to neuro-regeneration after traumatic spinal cord injury / Heller, Raban [VerfasserIn]; 2019 (Online-Ressource)