Relation of selenium status to neuro-regeneration after traumatic spinal cord injury

• Verfasst von: Heller, Raban [VerfasserIn]
• Verfasst von: Seelig, Julian [VerfasserIn]
• Verfasst von: Bock, Tobias [VerfasserIn]
• Verfasst von: Haubruck, Patrick [VerfasserIn]
• Verfasst von: Grützner, Paul Alfred [VerfasserIn]
• Verfasst von: Schomburg, Lutz [VerfasserIn]
• Verfasst von: Moghaddam-Alvandi, Arash [VerfasserIn]
• Verfasst von: Biglari, Bahram [VerfasserIn]
• Titel: Relation of selenium status to neuro-regeneration after traumatic spinal cord injury
• Verf.angabe: Raban Arved Heller, Julian Seelig, Tobias Bock, Patrick Haubruck, Paul Alfred Grützner, Lutz Schomburg, Arash Moghaddam, Bahram Biglari
• Jahr: 2019
• Jahr des Originals: 2018
• Umfang: 9 S.
• Fussnoten: Available online 12 October 2018 ; Gesehen am 09.07.2019
• Titel Quelle: Enthalten in: Journal of trace elements in medicine and biology
• Ort Quelle: München : Elsevier, 1995
• Jahr Quelle: 2019
• Band/Heft Quelle: 51(2019), Seite 141-149
• ISSN Quelle: 1878-3252
• DOI: doi:10.1016/j.jtemb.2018.10.006
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Biomarker
• Sach-SW: Brain
• Sach-SW: ELISA
• Sach-SW: Inflammation
• Sach-SW: Injury
• Sach-SW: Neurodegeneration
• Sach-SW: Neuron
• Sach-SW: Paraplegia
• Sach-SW: Precision medicine
• Sach-SW: Prediction
• Sach-SW: Profile
• Sach-SW: Recovery
• Sach-SW: Selenoprotein P
• Sach-SW: Supplementation
• Sach-SW: Surgery
• Sach-SW: Trace element
• Sach-SW: Zinc
• K10plus-PPN: 1668834472

Abstract

Introduction - The trace element selenium (Se) is crucial for the biosynthesis of selenoproteins. Both neurodevelopment and the survival of neurons that are subject to stress depend on a regular selenoprotein biosynthesis and sufficient Se supply by selenoprotein P (SELENOP). - Hypothesis - Neuro-regeneration after traumatic spinal cord injury (TSCI) is related to the Se status. - Study design - Single-centre prospective observational study. - Patients and methods - Three groups of patients with comparable injuries were studied; vertebral fractures without neurological impairment (n = 10, group C), patients with TSCI showing no remission (n = 9, group G0), and patients with remission developing positive abbreviated injury score (AIS) conversion within 3 months (n = 10, group G1). Serum samples were available from different time points (upon admission, and after 4, 9 and 12 h, 1 and 3 days, 1 and 2 weeks, and 1, 2 and 3 months). Serum trace element concentrations were determined by total reflection X-ray fluorescence, SELENOP by ELISA, and further parameters by laboratory routine. - Results - Serum Se and SELENOP concentrations were higher on admission in the remission group (G1) as compared to G0. During the first week, both parameters remained constant in C and G0, whereas they declined significantly in the remission group. Similarly, the concentration changes between admission and 24 h were most pronounced in this group of recovering patients (G1). Binary logistic regression analysis including the delta of Se and SELENOP within the first 24 h indicated an AUC of 90.0% (CI: 67.4%-100.0%) with regards to predicting the outcome after TSCI. - Conclusion - A Se deficit might constitute a risk factor for poor outcome after TSCI. A dynamic decline of serum Se and SELENOP concentrations after admission may reflect ongoing repair processes that are associated with higher odds for a positive clinical outcome.