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Verfasst von:Heller, Raban [VerfasserIn]   i
 Seelig, Julian [VerfasserIn]   i
 Bock, Tobias [VerfasserIn]   i
 Haubruck, Patrick [VerfasserIn]   i
 Grützner, Paul Alfred [VerfasserIn]   i
 Schomburg, Lutz [VerfasserIn]   i
 Moghaddam-Alvandi, Arash [VerfasserIn]   i
 Biglari, Bahram [VerfasserIn]   i
Titel:Relation of selenium status to neuro-regeneration after traumatic spinal cord injury
Verf.angabe:Raban Arved Heller, Julian Seelig, Tobias Bock, Patrick Haubruck, Paul Alfred Grützner, Lutz Schomburg, Arash Moghaddam, Bahram Biglari
Jahr:2019
Jahr des Originals:2018
Umfang:9 S.
Fussnoten:Available online 12 October 2018 ; Gesehen am 09.07.2019
Titel Quelle:Enthalten in: Journal of trace elements in medicine and biology
Ort Quelle:München : Elsevier, 1995
Jahr Quelle:2019
Band/Heft Quelle:51(2019), Seite 141-149
ISSN Quelle:1878-3252
Abstract:Introduction - The trace element selenium (Se) is crucial for the biosynthesis of selenoproteins. Both neurodevelopment and the survival of neurons that are subject to stress depend on a regular selenoprotein biosynthesis and sufficient Se supply by selenoprotein P (SELENOP). - Hypothesis - Neuro-regeneration after traumatic spinal cord injury (TSCI) is related to the Se status. - Study design - Single-centre prospective observational study. - Patients and methods - Three groups of patients with comparable injuries were studied; vertebral fractures without neurological impairment (n = 10, group C), patients with TSCI showing no remission (n = 9, group G0), and patients with remission developing positive abbreviated injury score (AIS) conversion within 3 months (n = 10, group G1). Serum samples were available from different time points (upon admission, and after 4, 9 and 12 h, 1 and 3 days, 1 and 2 weeks, and 1, 2 and 3 months). Serum trace element concentrations were determined by total reflection X-ray fluorescence, SELENOP by ELISA, and further parameters by laboratory routine. - Results - Serum Se and SELENOP concentrations were higher on admission in the remission group (G1) as compared to G0. During the first week, both parameters remained constant in C and G0, whereas they declined significantly in the remission group. Similarly, the concentration changes between admission and 24 h were most pronounced in this group of recovering patients (G1). Binary logistic regression analysis including the delta of Se and SELENOP within the first 24 h indicated an AUC of 90.0% (CI: 67.4%-100.0%) with regards to predicting the outcome after TSCI. - Conclusion - A Se deficit might constitute a risk factor for poor outcome after TSCI. A dynamic decline of serum Se and SELENOP concentrations after admission may reflect ongoing repair processes that are associated with higher odds for a positive clinical outcome.
DOI:doi:10.1016/j.jtemb.2018.10.006
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.jtemb.2018.10.006
 Volltext: http://www.sciencedirect.com/science/article/pii/S0946672X18304577
 DOI: https://doi.org/10.1016/j.jtemb.2018.10.006
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Biomarker
 Brain
 ELISA
 Inflammation
 Injury
 Neurodegeneration
 Neuron
 Paraplegia
 Precision medicine
 Prediction
 Profile
 Recovery
 Selenoprotein P
 Supplementation
 Surgery
 Trace element
 Zinc
K10plus-PPN:1668834472
Verknüpfungen:→ Zeitschrift

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