Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Kleggetveit, Inge Petter [VerfasserIn]   i
 Schmelz, Martin [VerfasserIn]   i
Titel:Pathological nociceptors in two patients with erythromelalgia-like symptoms and rare genetic Nav 1.9 variants
Verf.angabe:Inge P. Kleggetveit, Roland Schmidt, Barbara Namer, Hugh Salter, Tormod Helås, Martin Schmelz, Ellen Jørum
E-Jahr:2016
Jahr:21 July 2016
Umfang:5 S.
Fussnoten:Gesehen am 10.07.2019
Titel Quelle:Enthalten in: Brain and behavior
Ort Quelle:Malden, Mass. : Wiley, 2011
Jahr Quelle:2016
Band/Heft Quelle:6(2016,10), Artikel-Nummer e00528, 5 Seiten
ISSN Quelle:2162-3279
Abstract:Introduction The sodium channel Nav 1.9 is expressed in peripheral nociceptors and has recently been linked to human pain conditions, but the exact role of Nav 1.9 for human nociceptor excitability is still unclear. Methods C-nociceptors from two patients with late onset of erythromelalgia-like pain, signs of small fiber neuropathy, and rare genetic variants of Nav 1.9 (N1169S, I1293V) were assessed by microneurography. Results Compared with patients with comparable pain phenotypes (erythromelalgia-like pain without Nav-mutations and painful polyneuropathy), there was a tendency toward more activity-dependent slowing of conduction velocity in mechanoinsensitive C-nociceptors. Hyperexcitability to heating and electrical stimulation were seen in some nociceptors, and other unspecific signs of increased excitability, including spontaneous activity and mechanical sensitization, were also observed. Conclusions Although the functional roles of these genetic variants are still unknown, the microneurography findings may be compatible with increased C-nociceptor excitability based on increased Nav 1.9 function.
DOI:doi:10.1002/brb3.528
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1002/brb3.528
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/brb3.528
 DOI: https://doi.org/10.1002/brb3.528
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:microneurography
 nociceptors
 pain
K10plus-PPN:1668922606
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68406937   QR-Code
zum Seitenanfang