Biological activities of suilysin

• Verfasst von: Tenenbaum, Tobias [VerfasserIn]
• Verfasst von: Schroten, Horst [VerfasserIn]
• Verfasst von: Schwerk, Christian [VerfasserIn]
• Titel: Biological activities of suilysin
• Titelzusatz: role in Streptococcus suis pathogenesis
• Verf.angabe: Tobias Tenenbaum, Tauseef M. Asmat, Maren Seitz, Horst Schroten and Christian Schwerk
• E-Jahr: 2016
• Jahr: 30 Jun 2016
• Umfang: 14 S.
• Fussnoten: Gesehen am 11.07.2019
• Titel Quelle: Enthalten in: Future microbiology
• Ort Quelle: London : Taylor & Francis, 2006
• Jahr Quelle: 2016
• Band/Heft Quelle: 11(2016), 7, Seite 941-954
• ISSN Quelle: 1746-0921
• DOI: doi:10.2217/fmb-2016-0028
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1669016250

Abstract

Streptococcus suis is an important swine and zoonotic pathogen equipped with several virulence factors. The pore-forming toxins are the most abundant bacterial toxins and classified as critical virulence (associated) factors of several pathogens. The role of suilysin (SLY), a pore-forming cholesterol-dependent cytolysin of S. suis, as a true virulence factor is under debate. Most of the bacterial toxins have been reported to modulate the host immune system to facilitate invasion and subsequent replication of bacteria within respective host cells. SLY has been demonstrated to play an important role in the pathogenesis of S. suis infection and inflammatory response in vitro and in vivo. This review highlights the contributions of SLY to the pathogenicity of S. suis. It will address its role during the development of S. suis meningitis in pigs, as well as humans, and discuss SLY as a potential vaccine candidate.