Mysteries in embryonic development

• Verfasst von: Schneider, Isabell [VerfasserIn]
• Verfasst von: Ellenberg, Jan [VerfasserIn]
• Titel: Mysteries in embryonic development
• Titelzusatz: How can errors arise so frequently at the beginning of mammalian life?
• Verf.angabe: Isabell Schneider, Jan Ellenberg
• E-Jahr: 2019
• Jahr: March 6, 2019
• Umfang: 12 S.
• Fussnoten: Gesehen am 11.07.2019
• Titel Quelle: Enthalten in: Public Library of SciencePLoS biology
• Ort Quelle: Lawrence, KS : PLoS, 2003
• Jahr Quelle: 2019
• Band/Heft Quelle: 17(2019,3) Artikel-Nummer e3000173
• ISSN Quelle: 1545-7885
• DOI: doi:10.1371/journal.pbio.3000173
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Cell cycle and cell division
• Sach-SW: Centrioles
• Sach-SW: Embryos
• Sach-SW: Mammalian genomics
• Sach-SW: Meiosis
• Sach-SW: Mitosis
• Sach-SW: Oocytes
• Sach-SW: Zygotes
• K10plus-PPN: 1669033678

Abstract

Chromosome segregation errors occur frequently during female meiosis but also in the first mitoses of mammalian preimplantation development. Such errors can lead to aneuploidy, spontaneous abortions, and birth defects. Some of the mechanisms underlying these errors in meiosis have been deciphered but which mechanisms could cause chromosome missegregation in the first embryonic cleavage divisions is mostly a “mystery”. In this article, we describe the starting conditions and challenges of these preimplantation divisions, which might impair faithful chromosome segregation. We also highlight the pending research to provide detailed insight into the mechanisms and regulation of preimplantation mitoses.