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Verfasst von:Eichinger, Monika [VerfasserIn]   i
 Optažaite, Daiva-Elžbieta [VerfasserIn]   i
 Kopp-Schneider, Annette [VerfasserIn]   i
 Hintze, Christian [VerfasserIn]   i
 Biederer, Jürgen [VerfasserIn]   i
 Niemann, Anne [VerfasserIn]   i
 Mall, Marcus A. [VerfasserIn]   i
 Wielpütz, Mark Oliver [VerfasserIn]   i
 Kauczor, Hans-Ulrich [VerfasserIn]   i
 Puderbach, Michael [VerfasserIn]   i
Titel:Morphologic and functional scoring of cystic fibrosis lung disease using MRI
Verf.angabe:Monika Eichinger, Daiva-Elzbieta Optazaite, Annette Kopp-Schneider, Christian Hintze, Jürgen Biederer, Anne Niemann, Marcus A. Mall, Mark O. Wielpütz, Hans-Ulrich Kauczor, Michael Puderbach
Jahr:2012
Jahr des Originals:2011
Umfang:9 S.
Fussnoten:Available online 23 March 2011 ; Gesehen am 11.07.2019
Titel Quelle:Enthalten in: European journal of radiology
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1990
Jahr Quelle:2012
Band/Heft Quelle:81(2012), 6, Seite 1321-1329
ISSN Quelle:1872-7727
Abstract:Magnetic resonance imaging (MRI) gains increasing importance in the assessment of cystic fibrosis (CF) lung disease. The aim of this study was to develop a morpho-functional MR-scoring-system and to evaluate its intra- and inter-observer reproducibility and clinical practicability to monitor CF lung disease over a broad severity range from infancy to adulthood. 35 CF patients with broad age range (mean 15.3years; range 0.5-42) were examined by morphological and functional MRI. Lobe based analysis was performed for parameters bronchiectasis/bronchial-wall-thickening, mucus plugging, abscesses/sacculations, consolidations, special findings and perfusion defects. The maximum global score was 72. Two experienced radiologists scored the images at two time points (interval 10weeks). Upper and lower limits of agreement, concordance correlation coefficients (CCC), total deviation index and coverage probability were calculated for global, morphology, function, component and lobar scores. Global scores ranged from 6 to 47. Intra- and inter-reader agreement for global scores were good (CCC: 0.98 (R1), 0.94 (R2), 0.97 (R1/R2)) and were comparable between high and low scores. Our results indicate that the proposed morpho-functional MR-scoring-system is reproducible and applicable for semi-quantitative evaluation of a large spectrum of CF lung disease severity. This scoring-system can be applied for the routine assessment of CF lung disease and maybe as endpoint for clinical trials.
DOI:doi:10.1016/j.ejrad.2011.02.045
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.ejrad.2011.02.045
 Volltext: http://www.sciencedirect.com/science/article/pii/S0720048X11002312
 DOI: https://doi.org/10.1016/j.ejrad.2011.02.045
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Cystic fibrosis
 Lung disease
 Magnetic resonance imaging (MRI)
 Reproducibility
 Scoring system
K10plus-PPN:1669054381
Verknüpfungen:→ Zeitschrift

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