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Verfasst von:Melnik, Svitlana [VerfasserIn]   i
 Boeuf, Stephane [VerfasserIn]   i
 Richter, Wiltrud [VerfasserIn]   i
Titel:Impact of c-MYC expression on proliferation, differentiation, and risk of neoplastic transformation of human mesenchymal stromal cells
Verf.angabe:Svitlana Melnik, Nadine Werth, Stephane Boeuf, Eva-Maria Hahn, Tobias Gotterbarm, Martina Anton and Wiltrud Richter
E-Jahr:2019
Jahr:5 March 2019
Umfang:18 S.
Teil:volume:10
 year:2019
 elocationid:73
 pages:1-18
 extent:18
Fussnoten:Gesehen am 15.07.2019
Titel Quelle:Enthalten in: Stem cell research & therapy
Ort Quelle:London : BioMed Central, 2010
Jahr Quelle:2019
Band/Heft Quelle:10(2019), Artikel-ID 73, Seite 1-18
ISSN Quelle:1757-6512
Abstract:Mesenchymal stromal cells isolated from bone marrow (MSC) represent an attractive source of adult stem cells for regenerative medicine. However, thorough research is required into their clinical application safety issues concerning a risk of potential neoplastic degeneration in a process of MSC propagation in cell culture for therapeutic applications. Expansion protocols could preselect MSC with elevated levels of growth-promoting transcription factors with oncogenic potential, such as c-MYC. We addressed the question whether c-MYC expression affects the growth and differentiation potential of human MSC upon extensive passaging in cell culture and assessed a risk of tumorigenic transformation caused by MSC overexpressing c-MYC in vivo.
DOI:doi:10.1186/s13287-019-1187-z
URL:Volltext: https://doi.org/10.1186/s13287-019-1187-z
 DOI: https://doi.org/10.1186/s13287-019-1187-z
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1669145484
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