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Verfasst von:Flechsig, Paul [VerfasserIn]   i
 Zabeck, Heike [VerfasserIn]   i
 Reubold, Sebastian [VerfasserIn]   i
 Sachpekidis, Christos [VerfasserIn]   i
 Rathke, Hendrik [VerfasserIn]   i
 Röhrich, Manuel [VerfasserIn]   i
 Heußel, Claus Peter [VerfasserIn]   i
 Harms, Alexander [VerfasserIn]   i
 Kauczor, Hans-Ulrich [VerfasserIn]   i
 Haberkorn, Uwe [VerfasserIn]   i
 Giesel, Frederik L. [VerfasserIn]   i
Titel:Impact of FDG-PET and dynamic contrast-enhanced MRI in comparison with DWI for N-staging in lung cancer patients
Verf.angabe:Paul Flechsig, Heike Zabeck, Sebastian Reubold, Christos Sachpekidis, Hendrik Rathke, Manuel Röhrich, Tim Holland-Letz, Claus-Peter Heussel, Alexander Harms, Hans-Ulrich Kauczor, Uwe Haberkorn, and Frederik L. Giesel
Jahr:2019
Jahr des Originals:2018
Fussnoten:Accepted 2018 September 03 ; Gesehen am 15.07.2019
Titel Quelle:Enthalten in: Iranian journal of radiology
Ort Quelle:Tehran : TUMS Publications, 2003
Jahr Quelle:2019
Band/Heft Quelle:19(2019,1) Artikel-Nummer e68638, 10 Seiten
ISSN Quelle:2008-2711
Abstract:Regarding mediastinal N-staging in lung cancer patients, computed tomography (CT), magnetic resonance imaging (MRI), and integrated 18Fluorine-fluorodeoxyglucose-positron emission tomography/CT (18F-FDG-PET/CT) are the most widespread imaging methodologies in clinical routine.In order to further extract information from non-invasive staging, we evaluated the use of 18F-FDG-PET/CT and dynamic contrast enhanced (DCE) and diffusion-weighted imaging (DWI) MRI using histopathology as the diagnostic gold standard. A total number of 50 patients had undergone MRI of the chest within two weeks prior to surgery for histopathological proof. DCE-MRI was evaluated on the basis of region of interest (ROI)-based signal intensity/time (SI/T) curves in the respective mediastinal lymph nodes (LNs). In total, 28 LNs could be allocated to the corresponding histopathological findings, as well as to corresponding findings in 18F-FDG-PET/CT.Malignant LNs presented with significantly higher FDG uptake in PET. Significant differences between malignant and benign LNs were found for DCE-MRI regarding the parameters MaxE, 4-minutes value, SE, EP and EP/MaxE. In DWI-MRI, malignant LNs presented with significantly lower signal intensity compared to benign LNs (p < 0.01). An apparent diffusion coefficient (ADC) threshold of 1528 mm2/s was found to exclude malignancy for LNs that are above the threshold.18F-FDG-PET in addition with MRI that includes DWI might improve mediastinal N-staging, which is of interest in cases of FDG-equivocal LNs. An ADC threshold of 1528 mm2/s might potentially help to further classify LNs with indefinite PET-findings. DCE-MRI of mediastinal LNs seems not yet to be approved for clinical routine.
DOI:doi:10.5812/iranjradiol.68638
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.5812/iranjradiol.68638
 Volltext: http://iranjradiol.com/en/articles/68638.html
 DOI: https://doi.org/10.5812/iranjradiol.68638
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1669194485
Verknüpfungen:→ Zeitschrift

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