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Verfasst von:Schilder, Andreas [VerfasserIn]   i
 Magerl, Walter [VerfasserIn]   i
 Hoheisel, Ulrich [VerfasserIn]   i
 Klein, Thomas [VerfasserIn]   i
 Treede, Rolf-Detlef [VerfasserIn]   i
Titel:Electrical high-frequency stimulation of the human thoracolumbar fascia evokes long-term potentiation-like pain amplification
Verf.angabe:Andreas Schilder, Walter Magerl, Ulrich Hoheisel, Thomas Klein, Rolf-Detlef Treede
E-Jahr:2016
Jahr:October 2016
Umfang:9 S.
Fussnoten:Gesehen am 17.07.2019
Titel Quelle:Enthalten in: Pain
Ort Quelle:New York, NY [u.a.] : Lippincott Williams and Wilkins, 1975
Jahr Quelle:2016
Band/Heft Quelle:157(2016,10) Artikel-Nummer 2309, 9 Seiten
ISSN Quelle:1872-6623
Abstract:Nociceptive long-term potentiation, a use dependent increase in synaptic efficacy in the dorsal horn of the spinal cord is thought to contribute to the development of persistent pain states. So far, no study has analyzed the effects of high-frequency stimulation (HFS) of afferents from deep tissues (muscle and fascia) on pain perception in the back in humans. In 16 healthy volunteers, the multifidus muscle and the overlying thoracolumbar fascia were stimulated with electrical high-frequency pulses (5 × 100 pulses at 100 Hz) through bipolar concentric needle electrodes placed at lumbar level (L3/L4). Electrical pain thresholds were lower (P < 0.001) and pain ratings were higher for fascia compared with muscle stimulation (P < 0.05). For both tissues, pain ratings increased significantly across the five 100 Hz trains (from 15 to 22 numerical rating scale for fascia, from 8 to 12 numerical rating scale for muscle; both P < 0.01). Fascia HFS increased fascia pain ratings 2.17 times compared with the unconditioned control site (P < 0.001), but had no significant effect on pain sensitivity of the muscle. The HFS in muscle had no significant effect on muscle pain, but decreased pain sensitivity of the overlying fascia by 20% (P < 0.05). In additional experiments using the same electrodes and followed over >60 minutes post-HFS, potentiation by fascia HFS was similar to that of skin HFS. These findings show that the spinal input from the fascia can induce long-term changes in pain sensitivity for at least 60 minutes making it a candidate potentially contributing to nonspecific low back pain.
DOI:doi:10.1097/j.pain.0000000000000649
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1097/j.pain.0000000000000649
 Volltext: https://journals.lww.com/pain/fulltext/2016/10000/Electrical_high_frequency_stimulation_of_the_human.20.aspx
 DOI: https://doi.org/10.1097/j.pain.0000000000000649
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:166932351X
Verknüpfungen:→ Zeitschrift

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