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Verfasst von:Hoburg, Arnd Thomas [VerfasserIn]   i
 Siebold, Rainer [VerfasserIn]   i
 Fickert, Stefan [VerfasserIn]   i
Titel:Matrix-Associated autologous chondrocyte implantation Is an effective treatment at midterm follow-up in adolescents and young adults
Verf.angabe:Arnd Hoburg, Ingo Löer, Konrad Körsmeier, Rainer Siebold, Philipp Niemeyer, Stefan Fickert, and Klaus Ruhnau
E-Jahr:2019
Jahr: April 25, 2019
Umfang:7 S.
Fussnoten:Gesehen am 17.07.2019
Titel Quelle:Enthalten in: Orthopaedic journal of sports medicine
Ort Quelle:London [u.a.] : Sage, 2013
Jahr Quelle:2019
Band/Heft Quelle:7 (2019,4) Artikel-Nummer 232596711984107, 7 Seiten
ISSN Quelle:2325-9671
Abstract:Background: Autologous chondrocyte implantation (ACI) is an established method for treating cartilage defects in the knee of adult patients. However, less is known about its effectiveness in adolescents. Hypothesis: Third-generation matrix-associated ACI (MACI) using spheroids (co.don chondrosphere/Spherox) is an effective and safe treatment for articular cartilage defects in adolescents aged 15 to 17 years, with outcomes comparable with those for young adults aged 18 to 34 years. Study Design: Cohort study; Level of evidence, 3. - Methods: A total of 71 patients (29 adolescents, 42 young adults) who had undergone ACI using spheroids were evaluated retrospectively in this multicenter study. For adolescents, the mean defect size was 4.6 ± 2.4 cm2, and the follow-up range was 3.5 to 8.0 years (mean, 63.3 months). For young adults, the mean defect size was 4.7 ± 1.2 cm2, and the follow-up range was 3.8 to 4.3 years (mean, 48.4 months). At the follow-up assessment, outcomes were assessed by using validated questionnaires (Knee injury and Osteoarthritis Outcome Score [KOOS], International Knee Documentation Committee [IKDC] subjective knee evaluation form and current health assessment form, and modified Lysholm score), the magnetic resonance observation of cartilage repair tissue (MOCART) score, and if relevant, time to treatment failure. Safety was assessed by the treatment failure rate. - Results: No significant difference between the 2 study groups was found for KOOS, IKDC, or MOCART scores, with all patients achieving high functional values. A significant difference was found in the modified Lysholm score, favoring the young adult group over the adolescent group (22.3 ± 1.9 vs 21.0 ± 2.4, respectively; P ¼ .0123). There were no differences between the rates of treatment failure, with 3% in the adolescent group and 5% in the young adult group. - Conclusion: Third-generation MACI using spheroids is a safe and effective treatment for large cartilage defects of the knee in adolescents at midterm follow-up. Outcomes are comparable with those for young adults after ACI.
DOI:doi:10.1177/2325967119841077
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1177/2325967119841077
 Volltext: http://journals.sagepub.com/doi/10.1177/2325967119841077
 DOI: https://doi.org/10.1177/2325967119841077
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1669326756
Verknüpfungen:→ Zeitschrift

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