| Online-Ressource |
Verfasst von: | Eisel, David [VerfasserIn]  |
| Das, Krishna [VerfasserIn]  |
| Dickes, Elke [VerfasserIn]  |
| König, Rainer [VerfasserIn]  |
| Osen, Wolfram [VerfasserIn]  |
| Eichmüller, Stefan B. [VerfasserIn]  |
Titel: | Cognate interaction with CD4+ T cells instructs tumor-associated macrophages to acquire M1-like phenotype |
Verf.angabe: | David Eisel, Krishna Das, Elke Dickes, Rainer König, Wolfram Osen and Stefan B. Eichmüller |
E-Jahr: | 2019 |
Jahr: | 22 February 2019 |
Umfang: | 12 S. |
Fussnoten: | Gesehen am 23.07.2019 ; Im Titel ist "+" hochgestellt |
Titel Quelle: | Enthalten in: Frontiers in immunology |
Ort Quelle: | Lausanne : Frontiers Media, 2010 |
Jahr Quelle: | 2019 |
Band/Heft Quelle: | 10(2019) Artikel-Nummer 219, 12 Seiten |
ISSN Quelle: | 1664-3224 |
Abstract: | The immunosuppressive tumor microenvironment (TME) established by tumor cells, stromal cells and inhibitory immune cells counteracts the function of tumor reactive T cells. Tumor associated macrophages (TAMs) showing functional plasticity contribute to this process as so called M2-like macrophages can suppress the function of effector T cells and promote their differentiation into regulatory T cells (Tregs). Furthermore, tumor antigen specific CD4+ T effector cells can essentially sustain anti-tumoral immune responses as shown for various tumor entities, thus suggesting that cognate interaction between tumor antigen-specific CD4+ T cells and TAMs might shift the intra-tumoral M1/M2 ratio towards M1. This study demonstrates repolarization of M2 like PECs upon MHC II-restricted interaction with tumor specific CD4+ T cells in vitro as shown by extensive gene and protein expression analyses. Moreover, adoptive transfer of OVA-specific OT-II cells into C57BL/6 mice bearing OVA expressing IAb-/- tumors resulted in increased accumulation of M1-like TAMs with enhanced M1 associated gene and protein expression profiles. Thus, this paper highlights a so far underestimated function of the CD4+ T cell / TAM axis in re-conditioning the immunosuppressive tumor microenvironment. |
DOI: | doi:10.3389/fimmu.2019.00219 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3389/fimmu.2019.00219 |
| Volltext: https://www.frontiersin.org/articles/10.3389/fimmu.2019.00219/full |
| DOI: https://doi.org/10.3389/fimmu.2019.00219 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | adoptive T cell transfer (ACT) |
| CD206 |
| CD4 T cells |
| iNOS |
| M2 macrophage |
| T cell therapy |
| tumor associated macrophages |
| tumor microenvironment (TMA) |
K10plus-PPN: | 166963177X |
Verknüpfungen: | → Zeitschrift |
Cognate interaction with CD4+ T cells instructs tumor-associated macrophages to acquire M1-like phenotype / Eisel, David [VerfasserIn]; 22 February 2019 (Online-Ressource)