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Verfasst von:Dickerson, L. D. [VerfasserIn]   i
 Neoptolemos, John P. [VerfasserIn]   i
Titel:Differentiation of autoimmune pancreatitis from pancreatic cancer remains challenging
Verf.angabe:L.D. Dickerson, A. Farooq, F. Bano, J. Kleeff, R. Baron, M. Raraty, P. Ghaneh, R. Sutton, P. Whelan, F. Campbell, P. Healey, J.P. Neoptolemos, V.S. Yip
E-Jahr:2019
Jahr:27 February 2019
Umfang:8 S.
Fussnoten:Gesehen am 25.07.2019
Titel Quelle:Enthalten in: World journal of surgery
Ort Quelle:New York, NY : Springer, 1977
Jahr Quelle:2019
Band/Heft Quelle:43(2019), 6, Seite 1604-1611
ISSN Quelle:1432-2323
Abstract:Background Autoimmune pancreatitis (AIP) is an uncommon form of chronic pancreatitis. Whilst being corticosteroid responsive, AIP often masquerades radiologically as pancreatic neoplasia. Our aim is to appraise demographic, radiological and histological features in our cohort in order to differentiate AIP from pancreatic malignancy. - Methods Clinical, biochemical, histological and radiological details of all AIP patients 1997-2016 were analysed. The initial imaging was re-reviewed according to international guidelines by three blinded independent radiologists to evaluate features associated with autoimmune pancreatitis and pancreatic cancer. - Results There were a total of 45 patients: 25 in type 1 (55.5%), 14 type 2 (31.1%) and 6 AIP otherwise not specified (13.3%). The median (IQR) age was 57 (51-70) years. Thirty patients (66.6%) were male. Twenty-six patients (57.8%) had resection for suspected malignancy and one for symptomatic chronic pancreatitis. Three had histologically proven malignancy with concurrent AIP. Two patients died from recurrent pancreatic cancer following resection. Multidisciplinary team review based on radiology and clinical history dictated management. Resected patients (vs. non-resected group) were older (64 vs. 53, p = 0.003) and more frequently had co-existing autoimmune pathologies (22.2 vs. 55.6%, p = 0.022). Resected patients also presented with less classical radiological features of AIP, which are halo sign (0/25 vs. 3/17, p = 0.029) and loss of pancreatic clefts (18/25 vs. 17/17, p = 0.017). There were no differences in demographic features other than age. - Conclusion Despite international guidelines for diagnosing AIP, differentiation from pancreatic cancer remains challenging. Resection remains an important treatment option in suspected cancer or where conservative treatment fails.
DOI:doi:10.1007/s00268-019-04928-w
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1007/s00268-019-04928-w
 Volltext: http://link.springer.com/10.1007/s00268-019-04928-w
 DOI: https://doi.org/10.1007/s00268-019-04928-w
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1670046257
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