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Verfasst von:Fritzmann, Johannes [VerfasserIn]   i
 Contin, Pietro [VerfasserIn]   i
 Reißfelder, Christoph [VerfasserIn]   i
 Büchler, Markus W. [VerfasserIn]   i
 Rahbari, Nuh Nabi [VerfasserIn]   i
 Ulrich, Alexis [VerfasserIn]   i
Titel:Comparison of three classifications for lymph node evaluation in patients undergoing total mesorectal excision for rectal cancer
Verf.angabe:Johannes Fritzmann, Pietro Contin, Christoph Reissfelder, Markus W. Büchler, Jürgen Weitz, Nuh N. Rahbari, Alexis B. Ulrich
E-Jahr:2018
Jahr:9 March 2018
Umfang:12 S.
Fussnoten:Gesehen am 29.07.2019
Titel Quelle:Enthalten in: Langenbeck's archives of surgery
Ort Quelle:Berlin : Springer, 1948
Jahr Quelle:2018
Band/Heft Quelle:403(2018), 4, Seite 451-462
ISSN Quelle:1435-2451
Abstract:PurposeThe present study compared the prognostic value of the lymph node ratio (LNR) and the 6th and the 7th TNM edition as three different lymph node classifications for rectal cancer patients.MethodsA total of 630 patients who underwent total mesorectal excision for primary rectal cancer between October 2001 and December 2007 were included. Prognostic factors of overall survival were analyzed using Cox proportional hazards models.ResultsThe median follow-up was 36.1 months and the 5-year overall survival rate was 70.3 ± 4.7%. The median number of lymph nodes was 15.0 (12.0-19.0). All three lymph node evaluations correlated with survival (p < 0.0001). The assessment of nodal status in the 7th TNM edition enabled further prognostic stratification. The prognostic value of the three classifications were independent of neoadjuvant therapy and lymph node count. On multivariate analyses, the N2 stage of the 6th TNM edition (Hazard ratio 2.08; 95% confidence interval 1.21-3.58) and the N2b stage of the 7th TNM edition (2.18; 1.17-4.07) correlated with poor survival. A LNR of 0.42-0.69 was also associated with unfavorable prognosis (2.97; 1.46-6.03), as was an LNR > 0.69 (2.51; 1.04-6.05). The LNR did not provide prognostic information in addition to the N stage of the TNM classifications.ConclusionsThe evaluated lymph node classifications were of comparable prognostic utility in patients with rectal cancer. The LNR did not provide prognostic information in addition to the N stage of the TNM classifications.
DOI:doi:10.1007/s00423-018-1662-5
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1007/s00423-018-1662-5
 DOI: https://doi.org/10.1007/s00423-018-1662-5
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Lymph node
 Metastasis
 Rectal cancer
 Total mesorectal excision
K10plus-PPN:1670114627
Verknüpfungen:→ Zeitschrift

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