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Verfasst von:Bydder, Mark [VerfasserIn]   i
 Schad, Lothar R. [VerfasserIn]   i
Titel:Dynamic 23Na MRI
Titelzusatz:a non-invasive window on neuroglial-vascular mechanisms underlying brain function
Verf.angabe:Mark Bydder, Wafaa Zaaraoui, Ben Ridley, Manon Soubrier, Marie Bertinetti, Sylviane Confort-Gouny, Lothar Schad, Maxime Guye, Jean-Philippe Ranjeva
Jahr:2019
Jahr des Originals:2018
Umfang:10 S.
Fussnoten:Available online 4 October 2018 ; Im Titel ist die Zahl 23 hochgestellt ; Gesehen am 31.07.2019
Titel Quelle:Enthalten in: NeuroImage
Ort Quelle:Orlando, Fla. : Academic Press, 1992
Jahr Quelle:2019
Band/Heft Quelle:184(2019), Seite 771-780
ISSN Quelle:1095-9572
Abstract:A novel magnetic resonance imaging (MRI) acquisition and reconstruction method for obtaining a series of dynamic sodium 23Na-MRI acquisitions was designed to non-invasively assess the signal variations of brain sodium during a hand motor task in 14 healthy human volunteers on an ultra high field (7T) MR scanner. Regions undergoing activation and deactivation were identified with reference to conventional task-related BOLD functional MRI (fMRI). Activation observed in the left central regions, the supplementary motor areas and the left cerebellum induced an increase in the sodium signal observed at ultra short echo time and a decrease in the 23Na signal observed at long echo time. Based on a simple model of two distinct sodium pools (namely, restricted and mobile sodium), the ultra short echo time measures the totality of sodium whereas the long echo time is mainly sensitive to mobile sodium. This activation pattern is consistent with previously described processes related to an influx of Na+ into the intracellular compartments and a moderate increase in the cerebral blood volume (CBV). In contrast, deactivation observed in the right central regions ipsilateral to the movement, the precuneus and the left cerebellum induced a slight decrease in sodium signal at ultra short echo time and an increase of sodium signal at longer echo times. This inhibitory pattern is compatible with a slight decrease in CBV and an efflux of intracellular Na+ to the extracellular compartments that may reflect neural dendritic spine and astrocytic shrinkage, and an increase of sodium in the extracellular fraction. In conclusion, cerebral dynamic 23Na MRI experiments can provide access to the ionic transients following a functional task occurring within the neuro-glial-vascular ensemble. This has the potential to open up a novel non-invasive window on the mechanisms underlying brain function.
DOI:doi:10.1016/j.neuroimage.2018.09.071
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.neuroimage.2018.09.071
 Volltext: http://www.sciencedirect.com/science/article/pii/S1053811918319438
 DOI: https://doi.org/10.1016/j.neuroimage.2018.09.071
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:7T
 Brain
 Excitation
 fMRI
 Inhibition
 Motor system
 Na MRI
 Sodium
K10plus-PPN:1670323048
Verknüpfungen:→ Zeitschrift

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