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Verfasst von:Betge, Johannes [VerfasserIn]   i
 Ebert, Matthias [VerfasserIn]   i
Titel:MUC1, MUC2, MUC5AC, and MUC6 in colorectal cancer
Titelzusatz:expression profiles and clinical significance
Verf.angabe:Johannes Betge, Nora I. Schneider, Lars Harbaum, Marion J. Pollheimer, Richard A. Lindtner, Peter Kornprat, Matthias P. Ebert, Cord Langner
E-Jahr:2016
Jahr:14 June 2016
Umfang:11 S.
Fussnoten:Gesehen am 31.07.2019
Titel Quelle:Enthalten in: Virchows Archiv
Ort Quelle:Berlin : Springer, 1847
Jahr Quelle:2016
Band/Heft Quelle:469(2016), 3, Seite 255-265
ISSN Quelle:1432-2307
Abstract:Mucin glycoprotein expression can be altered during the carcinogenic process. The impact on the prognosis of patients with colorectal cancer (CRC) is controversial. We analyzed tumors from 381 patients for MUC1, MUC2, MUC5AC, and MUC6 expression by immunohistochemical staining, using tissue microarrays. Progression-free and cancer-specific survival were determined using the Kaplan-Meier method. Expression of intestinal mucin MUC2 was lost in 85 (23 %) CRCs, and patients with MUC6-negative tumors showed shorter progression-free survival (PFS, p = 0.043). Gastric mucins MUC5AC and MUC6 showed high (>50 %) aberrant expression in 28 (8 %) and 9 (2 %) cases, respectively. High expression of MUC5AC was associated with longer PFS (p = 0.055). High expression of MUC6 was associated with 100 % PFS (p = 0.024) and longer cancer-specific survival (CSS, p = 0.043). MUC1 was expressed in 238 (64 %) tumors and had no impact on outcome. When analysis was restricted to stages II and III, loss of MUC2 was associated with adverse outcome. Overexpression of both MUC5AC and MUC6 significantly predicted favorable PFS and CSS. In conclusion, loss of MUC2 expression proved to be a predictor of adverse outcome, while the gain of aberrant expression of MUC5AC and particularly of MUC6 was associated with favorable outcome in CRC, notably in intermediate stages II and III.
DOI:doi:10.1007/s00428-016-1970-5
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1007/s00428-016-1970-5
 DOI: https://doi.org/10.1007/s00428-016-1970-5
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Immunohistochemistry
 Large intestine
 Mucin
 Prognosis
 Prognostic factor
 Stage II
K10plus-PPN:167032477X
Verknüpfungen:→ Zeitschrift

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